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Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia

Kettyle, Laura M.J.; Liberante, Fabio G.; Thompson, Alexander


Laura M.J. Kettyle

Fabio G. Liberante


Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia.

Journal Article Type Article
Publication Date Jul 8, 2014
Journal Methods in Molecular Biology
Electronic ISSN 1940-6029
Peer Reviewed Peer Reviewed
Volume 1196
APA6 Citation Kettyle, L. M., Liberante, F. G., & Thompson, A. (2014). Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196, doi:10.1007/978-1-4939-1242-1_21
Keywords HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information The final publication is available at Springer via