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Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia

Kettyle, Laura M.J.; Liberante, Fabio G.; Thompson, Alexander

Authors

Laura M.J. Kettyle

Fabio G. Liberante



Abstract

Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia.

Journal Article Type Article
Publication Date Jul 8, 2014
Journal Methods in Molecular Biology
Electronic ISSN 1940-6029
Peer Reviewed Peer Reviewed
Volume 1196
APA6 Citation Kettyle, L. M., Liberante, F. G., & Thompson, A. (2014). Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196, doi:10.1007/978-1-4939-1242-1_21
DOI https://doi.org/10.1007/978-1-4939-1242-1_21
Keywords HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model
Publisher URL https://link.springer.com/protocol/10.1007%2F978-1-4939-1242-1_21
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4939-1242-1_21
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