Laura M.J. Kettyle
Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia
Kettyle, Laura M.J.; Liberante, Fabio G.; Thompson, Alexander
Abstract
Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia.
Citation
Kettyle, L. M., Liberante, F. G., & Thompson, A. (2014). Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196, https://doi.org/10.1007/978-1-4939-1242-1_21
Journal Article Type | Article |
---|---|
Acceptance Date | May 8, 2014 |
Publication Date | Jul 8, 2014 |
Deposit Date | May 12, 2017 |
Journal | Methods in Molecular Biology |
Electronic ISSN | 1940-6029 |
Peer Reviewed | Peer Reviewed |
Volume | 1196 |
DOI | https://doi.org/10.1007/978-1-4939-1242-1_21 |
Keywords | HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model |
Public URL | https://nottingham-repository.worktribe.com/output/732830 |
Publisher URL | https://link.springer.com/protocol/10.1007%2F978-1-4939-1242-1_21 |
Additional Information | The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4939-1242-1_21 |
Contract Date | May 12, 2017 |
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