Translating intracellular calcium signaling into models

Thul, Ruediger

Abstract

The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium modeling with a special emphasis on calcium-induced calcium release (CICR) through inositol-1,4,5-trisphosphate and ryanodine receptors. I will highlight key features of CICR and how they are represented in models as well as the challenges that theoreticians face when translating our current understanding of calcium signals into equations. The selected examples demonstrate that a successful model provides mechanistic insights into the molecular machinery of the Ca2+ signaling toolbox and determines the contribution of local Ca2+ release to global Ca2+ patterns, which at the moment cannot be resolved experimentally.

Citation

Thul, R. (2014). Translating intracellular calcium signaling into models. Cold Spring Harbor protocols, https://doi.org/10.1101/pdb.top066266

• Journal Article Type: Article
• Acceptance Date: Nov 1, 2013
• Publication Date: May 15, 2014
• Deposit Date: Jun 17, 2016
• Publicly Available Date: Jun 17, 2016
• Journal: Cold Spring Harbor Protocols
• Electronic ISSN: 1559-6095
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1101/pdb.top066266
• Public URL: https://nottingham-repository.worktribe.com/output/728708
• Publisher URL: http://cshprotocols.cshlp.org/content/2014/5/pdb.top066266