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Translating intracellular calcium signaling into models

Thul, Ruediger

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Abstract

The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium modeling with a special emphasis on calcium-induced calcium release (CICR) through inositol-1,4,5-trisphosphate and ryanodine receptors. I will highlight key features of CICR and how they are represented in models as well as the challenges that theoreticians face when translating our current understanding of calcium signals into equations. The selected examples demonstrate that a successful model provides mechanistic insights into the molecular machinery of the Ca2+ signaling toolbox and determines the contribution of local Ca2+ release to global Ca2+ patterns, which at the moment cannot be resolved experimentally.

Journal Article Type Article
Publication Date May 15, 2014
Journal Cold Spring Harbor Protocols
Electronic ISSN 1559-6095
Peer Reviewed Peer Reviewed
APA6 Citation Thul, R. (2014). Translating intracellular calcium signaling into models. Cold Spring Harbor protocols, https://doi.org/10.1101/pdb.top066266
DOI https://doi.org/10.1101/pdb.top066266
Publisher URL http://cshprotocols.cshlp.org/content/2014/5/pdb.top066266
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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