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Translating intracellular calcium signaling into models

Thul, Ruediger

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The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium modeling with a special emphasis on calcium-induced calcium release (CICR) through inositol-1,4,5-trisphosphate and ryanodine receptors. I will highlight key features of CICR and how they are represented in models as well as the challenges that theoreticians face when translating our current understanding of calcium signals into equations. The selected examples demonstrate that a successful model provides mechanistic insights into the molecular machinery of the Ca2+ signaling toolbox and determines the contribution of local Ca2+ release to global Ca2+ patterns, which at the moment cannot be resolved experimentally.


Thul, R. (2014). Translating intracellular calcium signaling into models. Cold Spring Harbor Protocols,

Journal Article Type Article
Acceptance Date Nov 1, 2013
Publication Date May 15, 2014
Deposit Date Jun 17, 2016
Publicly Available Date Jun 17, 2016
Journal Cold Spring Harbor Protocols
Print ISSN 1940-3402
Electronic ISSN 1559-6095
Publisher Cold Spring Harbor Laboratory Press
Peer Reviewed Peer Reviewed
Public URL
Publisher URL
Contract Date Jun 17, 2016


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