Neural primacy of the salience processing system in schizophrenia
Palaniyappan, Lena; Simmonite, M.; White, T.P.; Liddle, E.B.; Liddle, P.F.
For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia.
Palaniyappan, L., Simmonite, M., White, T., Liddle, E., & Liddle, P. (2013). Neural primacy of the salience processing system in schizophrenia. Neuron, 79(4), doi:10.1016/j.neuron.2013.06.027
|Journal Article Type||Article|
|Publication Date||Aug 21, 2013|
|Deposit Date||Apr 2, 2014|
|Publicly Available Date||Apr 2, 2014|
|Peer Reviewed||Peer Reviewed|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0