Javier T. Granados-Riveron
Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics
Granados-Riveron, Javier T.; Brook, David
Abstract
Congenital heart disease (CHD) is the most common birth defect in humans. It is a leading infant mortality factor worldwide, caused by defective cardiac development. Mutations in transcription factors, signalling and structural molecules have been shown to contribute to the genetic component of CHD. Recently, mutations in genes encoding myofibrillar proteins expressed in the embryonic heart have also emerged as an important genetic causative factor of the disease, which implies that the contraction of the early heart primordium contributes to its morphogenesis. This notion is supported by increasing evidence suggesting that not only contraction but also formation, mechanosensing, and mechanotransduction of the cardiac myofibrillar proteins influence heart development. In this paper, we summarize the genetic clues supporting this idea.
Citation
Granados-Riveron, J. T., & Brook, D. (2012). Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics. Biochemistry Research International, 2012(504906), https://doi.org/10.1155/2012/504906
Journal Article Type | Article |
---|---|
Publication Date | Apr 15, 2012 |
Deposit Date | Mar 24, 2014 |
Publicly Available Date | Mar 29, 2024 |
Journal | Biochemistry Research International |
Print ISSN | 2090-2247 |
Electronic ISSN | 2090-2247 |
Publisher | Hindawi Publishing Corporation |
Peer Reviewed | Peer Reviewed |
Volume | 2012 |
Issue | 504906 |
DOI | https://doi.org/10.1155/2012/504906 |
Public URL | https://nottingham-repository.worktribe.com/output/709938 |
Publisher URL | http://www.hindawi.com/journals/bri/2012/504906/ |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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