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Both, toxin A and toxin B, are important in Clostridium difficile infection

Kuehne, Sarah A.; Cartman, Stephen T.; Minton, Nigel P.

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Authors

Sarah A. Kuehne

Stephen T. Cartman



Abstract

The bacterium Clostridium difficile is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of C. difficile are two large toxins, A and B. Over the years there has been some debate over the respective roles and importance of these two toxins. To address this, we recently constructed stable toxin mutants of C. difficile and found that they were virulent if either toxin A or toxin B was functional. This underlined the importance of each toxin and the necessity to consider both when developing countermeasures against Clostridium difficile infection (CDI). In this article we discuss our findings in the context of previous work and outline some of the challenges which face the field as a result.

Citation

Kuehne, S. A., Cartman, S. T., & Minton, N. P. (2011). Both, toxin A and toxin B, are important in Clostridium difficile infection. Gut Microbes, 2(4), https://doi.org/10.4161/gmic.2.4.16109

Journal Article Type Article
Publication Date Jul 1, 2011
Deposit Date Apr 29, 2014
Publicly Available Date Mar 29, 2024
Journal Gut Microbes
Print ISSN 1949-0976
Electronic ISSN 1949-0976
Publisher Taylor & Francis Open
Peer Reviewed Peer Reviewed
Volume 2
Issue 4
DOI https://doi.org/10.4161/gmic.2.4.16109
Keywords Clostridium difficile, Toxin A, Toxin B, Clostridium difficile infection
Public URL https://nottingham-repository.worktribe.com/output/707556
Publisher URL https://www.landesbioscience.com/journals/gutmicrobes/article/16109/

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