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Both, toxin A and toxin B, are important in Clostridium difficile infection

Kuehne, Sarah A.; Cartman, Stephen T.; Minton, Nigel P.

Authors

Sarah A. Kuehne sarah.keuhne@nottingham.av.uk

Stephen T. Cartman

Nigel P. Minton nigel.minton@nottingham.ac.uk



Abstract

The bacterium Clostridium difficile is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of C. difficile are two large toxins, A and B. Over the years there has been some debate over the respective roles and importance of these two toxins. To address this, we recently constructed stable toxin mutants of C. difficile and found that they were virulent if either toxin A or toxin B was functional. This underlined the importance of each toxin and the necessity to consider both when developing countermeasures against Clostridium difficile infection (CDI). In this article we discuss our findings in the context of previous work and outline some of the challenges which face the field as a result.

Journal Article Type Article
Publication Date Jul 1, 2011
Journal Gut Microbes
Print ISSN 1949-0976
Electronic ISSN 1949-0976
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 2
Issue 4
Institution Citation Kuehne, S. A., Cartman, S. T., & Minton, N. P. (2011). Both, toxin A and toxin B, are important in Clostridium difficile infection. Gut Microbes, 2(4), doi:10.4161/gmic.2.4.16109
DOI https://doi.org/10.4161/gmic.2.4.16109
Keywords Clostridium difficile, Toxin A, Toxin B, Clostridium difficile infection
Publisher URL https://www.landesbioscience.com/journals/gutmicrobes/article/16109/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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