The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia
Driver, Ian; Blockley, Nicholas; Fisher, Joseph; Francis, Susan; Gowland, Penny A.
Penny A. Gowland
Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T.
|Journal Article Type||Article|
|Publication Date||May 15, 2010|
|Peer Reviewed||Peer Reviewed|
|Institution Citation||Driver, I., Blockley, N., Fisher, J., Francis, S., & Gowland, P. A. (2010). The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia. NeuroImage, 51(1), doi:10.1016/j.neuroimage.2009.12.113|
|Related Public URLs||http://dx.doi.org/10.1016/j.neuroimage.2009.12.113|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf