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The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia

Driver, Ian; Blockley, Nicholas; Fisher, Joseph; Francis, Susan; Gowland, Penny A.


Ian Driver

Nicholas Blockley

Joseph Fisher

Susan Francis

Penny A. Gowland


Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T.

Journal Article Type Article
Publication Date May 15, 2010
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1053-8119
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 51
Issue 1
Institution Citation Driver, I., Blockley, N., Fisher, J., Francis, S., & Gowland, P. A. (2010). The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia. NeuroImage, 51(1), doi:10.1016/j.neuroimage.2009.12.113
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Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf


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