The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia

Driver, Ian; Blockley, Nicholas; Fisher, Joseph; Francis, Susan; Gowland, Penny A.

Abstract

Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T.

Citation

Driver, I., Blockley, N., Fisher, J., Francis, S., & Gowland, P. A. (2010). The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia. NeuroImage, 51(1), https://doi.org/10.1016/j.neuroimage.2009.12.113

• Journal Article Type: Article
• Publication Date: May 15, 2010
• Deposit Date: Jun 17, 2010
• Publicly Available Date: Jun 17, 2010
• Journal: NeuroImage
• Print ISSN: 1053-8119
• Electronic ISSN: 1095-9572
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 1
• DOI: https://doi.org/10.1016/j.neuroimage.2009.12.113
• Public URL: https://nottingham-repository.worktribe.com/output/706319
• Publisher URL: http://www.elsevier.com/locate/ynimg
• Related Public URLs: http://dx.doi.org/10.1016/j.neuroimage.2009.12.113