M.A. Hyatt
Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep
Hyatt, M.A.; Budge, H; Walker, D; Stephenson, T; Symonds, Michael E.
Authors
Professor Helen Budge HELEN.BUDGE@NOTTINGHAM.AC.UK
PROFESSOR OF NEONATAL MEDICINE
D Walker
T Stephenson
Michael E. Symonds
Abstract
The liver is an important metabolic and endocrine organ in the fetus but the extent to which its hormone receptor (R) sensitivity is developmentally regulated in early life is not fully established. We, therefore, examined developmental changes in mRNA abundance for the growth hormone (GH) and prolactin (PRL) receptors (R) plus insulin-like growth factor (IGF)-I and –II and their receptors. Fetal and postnatal sheep were sampled at either 80, or 140 days gestation, 1, 30 days or six months of age. The effect of maternal nutrient restriction between early to mid (i.e. 28 to 80 days gestation, the time of early liver growth) gestation on gene expression was also examined in the fetus and juvenile offspring. Gene expression for the GHR, PRLR and IGF-IR increased through gestation peaking at birth, whereas IGF-I was maximal near to term. In contrast, IGF-II mRNA decreased between mid and late gestation to increase after birth whereas IGF-IIR remained unchanged. A substantial decline in mRNA abundance for GHR, PRLR and IGF-IR then occurred up to six months. Maternal nutrient restriction reduced GHR and IGF-IIR mRNA abundance in the fetus, but caused a precocious increase in the PRLR. Gene expression for IGF-I and –II were increased in juvenile offspring born to nutrient restricted mothers. In conclusion, there are marked differences in the developmental ontogeny and nutritional programming of specific hormones and their receptors involved in hepatic growth and development in the fetus. These could contribute to changes in liver function during adult life.
Citation
Hyatt, M., Budge, H., Walker, D., Stephenson, T., & Symonds, M. E. (2007). Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep. Endocrinology, 148(10), https://doi.org/10.1210/en.2007-0303
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 6, 2007 |
Publication Date | Oct 1, 2007 |
Deposit Date | Aug 18, 2008 |
Publicly Available Date | Aug 18, 2008 |
Journal | Endocrinology |
Print ISSN | 0013-7227 |
Electronic ISSN | 1945-7170 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 148 |
Issue | 10 |
DOI | https://doi.org/10.1210/en.2007-0303 |
Keywords | Growth hormone, insulin-like growth factor, prolactin receptor |
Public URL | https://nottingham-repository.worktribe.com/output/704266 |
Publisher URL | https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2007-0303 |
Additional Information | The final version of record is available at http://intl-endo.endojournals.org |
Contract Date | Aug 18, 2008 |
Files
Hyatt_Ontogeny_Endocrinology_2007.pdf
(188 Kb)
PDF
You might also like
Anti-reflux medication use in preterm infants
(2021)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search