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The pathogenesis of disease due to type b Haemophilus influenzae

Aubrey, R.; Tang, Christoph


Assistant Professor

Christoph Tang


Mark A. Herbert

Derek W. Hood

E. Richard Moxon


Haemophilus influenzae is a Gram-negative bacterium that was first described by Pfeiffer in 1892 (1). This ubiquitous, human-specific organism was originally thought to be the etiologic agent of “influenza.” However, H. influenzae was not consistently isolated from autopsied lungs of individuals who had died during the influenza pandemic in 1918. The confusion that existed about the relationship between the prevalence of H. influenzae and human disease was relieved when Pittman discovered that strains of this bacterium could be divided into two groups, encapsulated (typeable) and nonencapsulated (nontypeable) strains (2). Pittman further distinguished six encapsulated types of H. influenzae, designated a–f, by the serological specificities of their capsular polysaccharide (2).


Aubrey, R., & Tang, C. (2003). The pathogenesis of disease due to type b Haemophilus influenzae. In M. A. Herbert, D. W. Hood, & E. R. Moxon (Eds.), Haemophilus influenzae protocols. Humana Press Inc.

Publication Date Oct 31, 2003
Deposit Date Dec 13, 2017
Peer Reviewed Peer Reviewed
Issue 71
Series Title Methods in molecular medicine
Book Title Haemophilus influenzae protocols
ISBN 9780896039285
Keywords Antibiotics; Bacteria; Infection; Infectious disease; Tissue
Public URL
Publisher URL
Contract Date May 1, 2002