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Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

Wild, Jim M.; Porter, Joanna C.; Molyneaux, Philip L.; George, Peter M.; Stewart, Iain; Allen, Richard James; Aul, Raminder; Baillie, John Kenneth; Barratt, Shaney L.; Beirne, Paul; Bianchi, Stephen M.; Blaikley, John F.; Brooke, Jonathan; Chaudhuri, Nazia; Collier, Guilhem; Denneny, Emma K.; Docherty, Annemarie; Fabbri, Laura; Gibbons, Michael A.; Gleeson, Fergus V.; Gooptu, Bibek; Hall, Ian P.; Hanley, Neil A.; Heightman, Melissa; Hillman, Toby E.; Johnson, Simon R.; Jones, Mark G.; Khan, Fasihul; Lawson, Rod; Mehta, Puja; Mitchell, Jane A.; Platé, Manuela; Poinasamy, Krisnah; Quint, Jennifer K.; Rivera-Ortega, Pilar; Semple, Malcolm; Simpson, A. John; Smith, D.J.F.; Spears, Mark; Spencer, LIsa G.; Stanel, Stefan C.; Thickett, David R.; Thompson, A.A. Roger; Walsh, Simon L.F.; Weatherley, Nicholas D.; Weeks, Mark Everard; Wootton, Dan G.; Brightling, Chris E.; Chambers, Rachel C.; Ho, Ling-Pei; Jacob, Joseph; Piper Hanley, Karen; Wain, Louise V.; Jenkins, R. Gisli

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) Thumbnail


Authors

Jim M. Wild

Joanna C. Porter

Philip L. Molyneaux

Peter M. George

Iain Stewart

Richard James Allen

Raminder Aul

John Kenneth Baillie

Shaney L. Barratt

Paul Beirne

Stephen M. Bianchi

John F. Blaikley

Jonathan Brooke

Nazia Chaudhuri

Guilhem Collier

Emma K. Denneny

Annemarie Docherty

Laura Fabbri

Michael A. Gibbons

Fergus V. Gleeson

Bibek Gooptu

IAN HALL IAN.HALL@NOTTINGHAM.AC.UK
Professor of Molecular Medicine

Neil A. Hanley

Melissa Heightman

Toby E. Hillman

SIMON JOHNSON simon.johnson@nottingham.ac.uk
Professor of Respiratory Medicine

Mark G. Jones

Fasihul Khan

Rod Lawson

Puja Mehta

Jane A. Mitchell

Manuela Platé

Krisnah Poinasamy

Jennifer K. Quint

Pilar Rivera-Ortega

Malcolm Semple

A. John Simpson

D.J.F. Smith

Mark Spears

LIsa G. Spencer

Stefan C. Stanel

David R. Thickett

A.A. Roger Thompson

Simon L.F. Walsh

Nicholas D. Weatherley

Mark Everard Weeks

Dan G. Wootton

Chris E. Brightling

Rachel C. Chambers

Ling-Pei Ho

Joseph Jacob

Karen Piper Hanley

Louise V. Wain

R. Gisli Jenkins



Abstract

Introduction The COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD).

Methods and analysis The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment.

Ethics and dissemination All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals.

Conclusion This study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.

Journal Article Type Article
Acceptance Date Aug 19, 2021
Online Publication Date Sep 23, 2021
Publication Date Sep 23, 2021
Deposit Date Nov 1, 2021
Publicly Available Date Nov 5, 2021
Journal BMJ Open Respiratory Research
Electronic ISSN 2052-4439
Publisher BMJ
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Article Number e001049
DOI https://doi.org/10.1136/bmjresp-2021-001049
Keywords Pulmonary and Respiratory Medicine
Public URL https://nottingham-repository.worktribe.com/output/6604199
Publisher URL https://bmjopenrespres.bmj.com/content/8/1/e001049

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