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A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity disorder (ADHD) and Autism

Bellato, Alessio; Norman, Luke; Idrees, Iman; Ogawa, Carolina Y.; Waitt, Alice; Zuccolo, Pedro F.; Tye, Charlotte; Radua, Joaquim; Groom, Madeleine J.; Shephard, Elizabeth

A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity disorder (ADHD) and Autism Thumbnail


Authors

Alessio Bellato

Luke Norman

Iman Idrees

Carolina Y. Ogawa

Alice Waitt

Pedro F. Zuccolo

Charlotte Tye

Joaquim Radua

Elizabeth Shephard



Abstract

Altered performance monitoring is implicated in obsessive-compulsive disorder (OCD), Gilles de la Tourette syndrome (GTS), attention-deficit/hyperactivity disorder (ADHD) and autism. We conducted a systematic review and meta-analysis of electrophysiological correlates of performance monitoring (error-related negativity, ERN; error positivity, Pe; feedback-related negativity, FRN; feedback-P3) in individuals with OCD, GTS, ADHD or autism compared to control participants, or associations between correlates and symptoms/traits of these conditions. Meta-analyses on 97 studies (5890 participants) showed increased ERN in OCD (Hedge’s g = 0.54[CIs:0.44,0.65]) and GTS (g = 0.99[CIs:0.05,1.93]). OCD also showed increased Pe (g = 0.51[CIs:0.21,0.81]) and FRN (g = 0.50[CIs:0.26,0.73]). ADHD and autism showed reduced ERN (ADHD: g=-0.47[CIs:-0.67,-0.26]; autism: g=-0.61[CIs:-1.10,-0.13]). ADHD also showed reduced Pe (g=-0.50[CIs:-0.69,-0.32]). These findings suggest overlap in electrophysiological markers of performance monitoring alterations in four common neurodevelopmental conditions, with increased amplitudes of the markers in OCD and GTS and decreased amplitudes in ADHD and autism. Implications of these findings in terms of shared and distinct performance monitoring alterations across these neurodevelopmental conditions are discussed.

Citation

Bellato, A., Norman, L., Idrees, I., Ogawa, C. Y., Waitt, A., Zuccolo, P. F., …Shephard, E. (2021). A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity disorder (ADHD) and Autism. Neuroscience and Biobehavioral Reviews, 131, 964-987. https://doi.org/10.1016/j.neubiorev.2021.10.018

Journal Article Type Article
Acceptance Date Oct 15, 2021
Online Publication Date Oct 21, 2021
Publication Date 2021-12
Deposit Date Oct 28, 2021
Publicly Available Date Mar 29, 2024
Journal Neuroscience and Biobehavioral Reviews
Print ISSN 0149-7634
Electronic ISSN 1873-7528
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 131
Pages 964-987
DOI https://doi.org/10.1016/j.neubiorev.2021.10.018
Keywords Behavioral Neuroscience; Cognitive Neuroscience; Neuropsychology and Physiological Psychology
Public URL https://nottingham-repository.worktribe.com/output/6542275
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S0149763421004590
Additional Information This article is maintained by: Elsevier; Article Title: A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity disorder (ADHD) and Autism; Journal Title: Neuroscience & Biobehavioral Reviews; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.neubiorev.2021.10.018; Content Type: article; Copyright: © 2021 Elsevier Ltd. All rights reserved.