Francesca Biondo
Sex differences in neural correlates of common psychopathological symptoms in early adolescence
Biondo, Francesca; Thunell, Charlotte Nymberg; Xu, Bing; Chu, Congying; Jia, Tianye; Ing, Alex; Quinlan, Erin Burke; Tay, Nicole; Banaschewski, Tobias; Bokde, Arun L. W.; B�chel, Christian; Desrivi�res, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Lemaitre, Herv�; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Millenet, Sabina; Fr�hner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Barker, Edward D.; Schumann, Gunter; IMAGEN Consortium
Authors
Charlotte Nymberg Thunell
Bing Xu
Congying Chu
Tianye Jia
Alex Ing
Erin Burke Quinlan
Nicole Tay
Tobias Banaschewski
Arun L. W. Bokde
Christian B�chel
Sylvane Desrivi�res
Herta Flor
Vincent Frouin
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Jean-Luc Martinot
Herv� Lemaitre
Frauke Nees
Dimitri Papadopoulos Orfanos
Luise Poustka
Sabina Millenet
Juliane H. Fr�hner
Michael N. Smolka
Henrik Walter
Robert Whelan
Edward D. Barker
Gunter Schumann
IMAGEN Consortium
Abstract
Background Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence. Methods Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ). Results We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (p < 0.01, Cohen's d = -0.24), bilateral anterior and mid-cingulum (p < 0.05, Cohen's d = -0.18), right cerebellum and fusiform (p < 0.05, Cohen's d = -0.20) and left frontal superior and middle gyri (p < 0.05, Cohen's d = -0.26). Higher symptoms of hyperactivity/inattention were associated with lower GMV in all four brain clusters in boys, and with higher GMV in the temporoparietal-opercular and cerebellar-fusiform clusters in girls. Conclusions Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.
Citation
Biondo, F., Thunell, C. N., Xu, B., Chu, C., Jia, T., Ing, A., …IMAGEN Consortium. (2022). Sex differences in neural correlates of common psychopathological symptoms in early adolescence. Psychological Medicine, 52(14), 3086-3096. https://doi.org/10.1017/S0033291720005140
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 7, 2020 |
Online Publication Date | Mar 26, 2021 |
Publication Date | 2022-10 |
Deposit Date | Jun 17, 2021 |
Publicly Available Date | Jun 17, 2021 |
Journal | Psychological Medicine |
Print ISSN | 0033-2917 |
Electronic ISSN | 1469-8978 |
Publisher | Cambridge University Press |
Peer Reviewed | Peer Reviewed |
Volume | 52 |
Issue | 14 |
Pages | 3086-3096 |
DOI | https://doi.org/10.1017/S0033291720005140 |
Keywords | Applied Psychology; Psychiatry and Mental health |
Public URL | https://nottingham-repository.worktribe.com/output/5689931 |
Publisher URL | https://www.cambridge.org/core/journals/psychological-medicine/article/sex-differences-in-neural-correlates-of-common-psychopathological-symptoms-in-early-adolescence/67FD4ACA9FC8BF265A11314D11F77BB5 |
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