Ali S. Alyami
Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants
Alyami, Ali S.; Williams, Hannah G.; Argyriou, Konstantinos; Gunn, David; Wilkinson-Smith, Victoria; White, Jonathan R.; Alyami, Jaber; Gowland, Penny A.; Moran, Gordon W.; Hoad, Caroline L.
Authors
Hannah G. Williams
Konstantinos Argyriou
David Gunn
Victoria Wilkinson-Smith
Jonathan R. White
Jaber Alyami
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
GORDON MORAN GORDON.MORAN@NOTTINGHAM.AC.UK
Professor of Gastroenterology
CAROLINE HOAD CAROLINE.L.HOAD@NOTTINGHAM.AC.UK
Senior Research Fellow
Abstract
Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn’s disease. Aim: To determine the repeatability and inter- and intra-observer agreement of these measures in the prepared small bowel wall. Methods: Ten healthy participants were scanned at 3T on 2 separate occasions using T1 and T2 relaxometry, IVIM-DWI and MT sequences. Test–retest repeatability was assessed using the coefficient of variation (CoV) and intra-class correlation coefficients (ICCs) were used to evaluate the intra- and inter-observer agreement Results: Test–retest repeatability in the bowel wall was excellent for apparent diffusion coefficient (ADC), magnetisation transfer ratio (MTR), T1, and diffusion coefficient D (CoV 5%, 7%, 8%, and 10%, respectively), good for perfusion fraction (PF) (CoV 20%) and acceptable for T2 (CoV 21%). Inter-observer agreement was good for the T2, D and ADC (ICC = 0.89, 0.86, 0.76, respectively) and moderate for T1 (ICC = 0.55). Intra-observer agreement was similar to inter-observer agreement. Discussion: This study showed variable results between the different parameters measured. Test–retest repeatability was at least acceptable for all parameters except pseudo-diffusion coefficient D*. Good inter- and intra-observer agreement was obtained for T2, ADC and D, with these parameters performing best in this technical validation study.
Citation
Alyami, A. S., Williams, H. G., Argyriou, K., Gunn, D., Wilkinson-Smith, V., White, J. R., …Hoad, C. L. (2021). Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants. Magnetic Resonance Materials in Physics, Biology and Medicine, 34, 791-804. https://doi.org/10.1007/s10334-021-00931-2
Journal Article Type | Article |
---|---|
Acceptance Date | May 18, 2021 |
Online Publication Date | Jun 5, 2021 |
Publication Date | Jun 5, 2021 |
Deposit Date | Jun 7, 2021 |
Publicly Available Date | Jun 9, 2021 |
Journal | Magnetic Resonance Materials in Physics, Biology and Medicine |
Print ISSN | 0968-5243 |
Electronic ISSN | 1352-8661 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 34 |
Pages | 791-804 |
DOI | https://doi.org/10.1007/s10334-021-00931-2 |
Keywords | Small intestine · Multiparametric magnetic resonance imaging · Validation study |
Public URL | https://nottingham-repository.worktribe.com/output/5633634 |
Publisher URL | https://link.springer.com/article/10.1007%2Fs10334-021-00931-2 |
Files
Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants
(2 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Functional connectivity in MRI is driven by spontaneous BOLD events
(2015)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search