Adamu Belay
Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
Belay, Adamu; Gashu, Dawd; Joy, Edward J.M.; Lark, R. Murray; Chagumaira, Christopher; Likoswe, Blessings H.; Zerfu, Dilnesaw; Ander, E. Louise; Young, Scott D.; Bailey, Elizabeth H.; Broadley, Martin R.
Authors
Dawd Gashu
Edward J.M. Joy
MURRAY LARK MURRAY.LARK@NOTTINGHAM.AC.UK
Professor of Geoinformatics
Christopher Chagumaira
Blessings H. Likoswe
Dilnesaw Zerfu
E. Louise Ander
Scott D. Young
LIZ BAILEY LIZ.BAILEY@NOTTINGHAM.AC.UK
Professor of Environmental Geochemistry
MARTIN BROADLEY MARTIN.BROADLEY@NOTTINGHAM.AC.UK
Professor of Plant Nutrition
Abstract
Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopian National Micronutrient Survey (ENMS), a cross-sectional survey of young children, school-age children, women of reproductive age (WRA) and men conducted in all 9 regions and two city administration of Ethiopia. Serum Zn concentrations, measured using inductively coupled plasma-mass spectrometry (ICPMS), were compared to thresholds based on age, sex, fasting status, and time of blood collection, after adjusting for inflammation status. Median serum Zn concentration of the population was 57.5 μg dL . Overall, it is estimated that 72% of the population was Zn deficient, with high prevalence in all demographic groups. Spatial statistical analysis showed that there was spatial dependence in Zn status of WRA at distances of up to 45 km. Zinc deficiency is spatially dependent over short distances. Although WRA in most areas are likely to be Zn deficient, prevalence of deficiency varies at regional scale and between rural and urban inhabitants, suggesting there is scope to explore drivers of this variation, prioritize nutritional interventions, and to design more representative surveillance programs. −1
Citation
Belay, A., Gashu, D., Joy, E. J., Lark, R. M., Chagumaira, C., Likoswe, B. H., …Broadley, M. R. (2021). Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia. Scientific Reports, 11(1), Article 6510. https://doi.org/10.1038/s41598-021-85977-x
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 5, 2021 |
Online Publication Date | Mar 22, 2021 |
Publication Date | Dec 1, 2021 |
Deposit Date | Apr 25, 2021 |
Publicly Available Date | Apr 26, 2021 |
Journal | Scientific Reports |
Electronic ISSN | 2045-2322 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 1 |
Article Number | 6510 |
DOI | https://doi.org/10.1038/s41598-021-85977-x |
Public URL | https://nottingham-repository.worktribe.com/output/5433385 |
Publisher URL | https://www.nature.com/articles/s41598-021-85977-x |
Files
s41598-021-85977-x
(3.2 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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