Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation

Scott, S M; Simr�n, M; Farmer, A D; Dinning, P G; Carrington, E V; Benninga, M A; Burgell, R E; Dimidi, E; Fikree, A; Ford, A C; Fox, M; Hoad, C L; Knowles, C H; Krogh, K; Nugent, K; Remes-Troche, J M; Whelan, K; Corsetti, M

Abstract

Chronic constipation is a prevalent disorder that affects patients’ quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treatments to use and when. Over a decade ago, a Neurogastroenterology & Motility journal supplement devoted to the investigation and management of constipation was published (2009;21(Suppl.2)). This included seven articles, disseminating all themes covered during a preceding two-day meeting held in London, entitled ‘Current perspectives in chronic constipation: a scientific and clinical symposium’. In October 2018, the 3rd London Masterclass, entitled ‘Contemporary management of constipation’ was held, again over two days. All faculty members were invited to author two new review articles representing a collective synthesis of talks presented and discussions held during this meeting.
PURPOSE
This article represents the first of these reviews, addressing epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Clearly not all aspects of the condition can be covered in adequate detail; hence, there is a focus on particular ‘hot topics’ and themes that are of contemporary interest. The second review addresses management of chronic constipation, covering behavioural, conservative, medical and surgical therapies.

Citation

Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R. E., Dimidi, E., Fikree, A., Ford, A. C., Fox, M., Hoad, C. L., Knowles, C. H., Krogh, K., Nugent, K., Remes-Troche, J. M., Whelan, K., & Corsetti, M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Neurogastroenterology and Motility, 33(6), 1-21. https://doi.org/10.1111/nmo.14050

• Journal Article Type: Review
• Acceptance Date: Nov 6, 2020
• Online Publication Date: Dec 2, 2020
• Publication Date: 2021-06
• Deposit Date: Nov 11, 2020
• Publicly Available Date: Dec 3, 2021
• Journal: Neurogastroenterology & Motility
• Print ISSN: 1350-1925
• Electronic ISSN: 1365-2982
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 6
• Article Number: e14050
• Pages: 1-21
• DOI: https://doi.org/10.1111/nmo.14050
• Keywords: chronic constipation, diagnosis, epidemiology, IBS-C, investigation, pathophysiology
• Public URL: https://nottingham-repository.worktribe.com/output/5035169
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.14050
• Additional Information: Received: 2020-07-20; Accepted: 2020-11-06; Published: 2020-12-02