Skip to main content

Research Repository

Advanced Search

HiBC: a publicly available collection of bacterial strains isolated from the human gut

Hitch, Thomas C.A.; Masson, Johannes M.; Pauvert, Charlie; Bosch, Johanna; Nüchtern, Selina; Treichel, Nicole S.; Baloh, Marko; Razavi, Soheila; Afrizal, Afrizal; Kousetzi, Ntana; Aguirre, Andrea M.; Wylensek, David; Coates, Amy C.; Jennings, Susan A.V.; Panyot, Atscharah; Viehof, Alina; Schmitz, Matthias A.; Stuhrmann, Maximilian; Deis, Evelyn C.; Bisdorf, Kevin; Chiotelli, Maria D.; Lissin, Artur; Schober, Isabel; Witte, Julius; Cramer, Thorsten; Riedel, Thomas; Wende, Marie; Winter, Katrin A.; Amend, Lena; Riva, Alessandra; Trinh, Stefanie; Mitchell, Laura; Hartman, Jonathan; Berry, David; Seitz, Jochen; Bossert, Lukas C.; Grognot, Marianne; Allers, Thorsten; Strowig, Till; Pester, Michael; Abt, Birte; Reimer, Lorenz C.; Overmann, Jörg; Clavel, Thomas

HiBC: a publicly available collection of bacterial strains isolated from the human gut Thumbnail


Authors

Thomas C.A. Hitch

Johannes M. Masson

Charlie Pauvert

Johanna Bosch

Selina Nüchtern

Nicole S. Treichel

Marko Baloh

Soheila Razavi

Afrizal Afrizal

Ntana Kousetzi

Andrea M. Aguirre

David Wylensek

Amy C. Coates

Susan A.V. Jennings

Atscharah Panyot

Alina Viehof

Matthias A. Schmitz

Maximilian Stuhrmann

Evelyn C. Deis

Kevin Bisdorf

Maria D. Chiotelli

Artur Lissin

Isabel Schober

Julius Witte

Thorsten Cramer

Thomas Riedel

Marie Wende

Katrin A. Winter

Lena Amend

Alessandra Riva

Stefanie Trinh

Laura Mitchell

Jonathan Hartman

David Berry

Jochen Seitz

Lukas C. Bossert

Marianne Grognot

Till Strowig

Michael Pester

Birte Abt

Lorenz C. Reimer

Jörg Overmann

Thomas Clavel



Abstract

Numerous bacteria in the human gut microbiome remain unknown and/or have yet to be cultured. While collections of human gut bacteria have been published, few strains are accessible to the scientific community. We have therefore created a publicly available collection of bacterial strains isolated from the human gut. The Human intestinal Bacteria Collection (HiBC) (https://www.hibc.rwth-aachen.de) contains 340 strains representing 198 species within 29 families and 7 phyla, of which 29 previously unknown species are taxonomically described and named. These included two butyrate-producing species of Faecalibacterium and new dominant species associated with health and inflammatory bowel disease, Ruminococcoides intestinale and Blautia intestinihominis, respectively. Plasmids were prolific within the HiBC isolates, with almost half (46%) of strains containing plasmids, with a maximum of six within a strain. This included a broadly occurring plasmid (pBAC) that exists in three diverse forms across Bacteroidales species. Megaplasmids were identified within two strains, the pMMCAT megaplasmid is globally present within multiple Bacteroidales species. This collection of easily searchable and publicly available gut bacterial isolates will facilitate functional studies of the gut microbiome.

Citation

Hitch, T. C., Masson, J. M., Pauvert, C., Bosch, J., Nüchtern, S., Treichel, N. S., Baloh, M., Razavi, S., Afrizal, A., Kousetzi, N., Aguirre, A. M., Wylensek, D., Coates, A. C., Jennings, S. A., Panyot, A., Viehof, A., Schmitz, M. A., Stuhrmann, M., Deis, E. C., Bisdorf, K., …Clavel, T. (2025). HiBC: a publicly available collection of bacterial strains isolated from the human gut. Nature Communications, 16(1), Article 4203. https://doi.org/10.1038/s41467-025-59229-9

Journal Article Type Article
Acceptance Date Apr 14, 2025
Online Publication Date May 6, 2025
Publication Date 2025
Deposit Date May 21, 2025
Publicly Available Date May 22, 2025
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 16
Issue 1
Article Number 4203
DOI https://doi.org/10.1038/s41467-025-59229-9
Public URL https://nottingham-repository.worktribe.com/output/49263757
Publisher URL https://www.nature.com/articles/s41467-025-59229-9

Files





You might also like



Downloadable Citations