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Strategies for 1H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy



Subhradip Paul

Marina Carravetta

Ilya Kuprov

Philip T. F. Williamson


© 2020 The Authors. Published by Wiley-VCH GmbH Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected 14N NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.


Concistré, M., Paul, S., Carravetta, M., Kuprov, I., & Williamson, P. T. F. (2020). Strategies for 1H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy. Chemistry - A European Journal, 26(68), 15852-15854.

Journal Article Type Article
Acceptance Date Aug 17, 2020
Online Publication Date Nov 3, 2020
Publication Date Dec 4, 2020
Deposit Date Sep 14, 2020
Publicly Available Date Nov 4, 2021
Journal Chemistry - A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 26
Issue 68
Pages 15852-15854
Keywords General Chemistry
Public URL
Publisher URL


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