Strategies for 1H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy

Concistr�, Maria; Paul, Subhradip; Carravetta, Marina; Kuprov, Ilya; Williamson, Philip T. F.

Abstract

© 2020 The Authors. Published by Wiley-VCH GmbH Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected 14N NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.

Citation

Concistré, M., Paul, S., Carravetta, M., Kuprov, I., & Williamson, P. T. F. (2020). Strategies for 1H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy. Chemistry - A European Journal, 26(68), 15852-15854. https://doi.org/10.1002/chem.202003463

• Journal Article Type: Article
• Acceptance Date: Aug 17, 2020
• Online Publication Date: Nov 3, 2020
• Publication Date: Dec 4, 2020
• Deposit Date: Sep 14, 2020
• Publicly Available Date: Nov 4, 2021
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Electronic ISSN: 1521-3765
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 68
• Pages: 15852-15854
• DOI: https://doi.org/10.1002/chem.202003463
• Keywords: General Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/4903140
• Publisher URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202003463