Late diagnosis of chronic liver disease in a community cohort (UK biobank): determinants and impact on subsequent survival

Innes, H.; Morling, J.R.; Aspinall, E. A.; Goldberg, D. J.; Hutchinson, S. J.; Guha, I. N.

Abstract

BACKGROUND: Chronic liver disease (CLD) is frequently diagnosed at a late stage when prognosis is poor. We aimed to determine the patient factors associated with a late CLD diagnosis and its subsequent impact on survival in order to support early diagnosis initiatives.

METHODS: We identified participants of UK biobank (UKB) study who developed first-time advanced CLD within 5-years. We identified factors associated with late diagnosis via logistic regression, and used survival analysis to measure the association between late CLD diagnosis and mortality risk.

RESULTS: 725 UKB participants developed first-time advanced CLD event within 5-years. 83% of cases were diagnosed late. Late diagnosis was associated with aetiology; the odds of late diagnosis were twelve times higher for an individual with alcohol-related liver disease (ArLD) versus viral hepatitis (aOR:12.01;p

Citation

Innes, H., Morling, J., Aspinall, E. A., Goldberg, D. J., Hutchinson, S. J., & Guha, I. N. (2020). Late diagnosis of chronic liver disease in a community cohort (UK biobank): determinants and impact on subsequent survival. Public Health, 187, 165-171. https://doi.org/10.1016/j.puhe.2020.07.017

• Journal Article Type: Article
• Acceptance Date: Jul 16, 2020
• Online Publication Date: Sep 28, 2020
• Publication Date: 2020-10
• Deposit Date: Jul 20, 2020
• Publicly Available Date: Sep 29, 2021
• Journal: Public Health
• Print ISSN: 0033-3506
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 187
• Pages: 165-171
• DOI: https://doi.org/10.1016/j.puhe.2020.07.017
• Keywords: Public Health, Environmental and Occupational Health; General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/4778187
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0033350620303127