Jonathan S. Nguyen-Van-Tam
Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment
Nguyen-Van-Tam, Jonathan S.; Killingley, Ben; Enstone, Joanne; Hewitt, Michael; Pantelic, Jovan; Grantham, Michael L.; Bueno de Mesquita, P. Jacob; Lambkin-Williams, Robert; Gilbert, Anthony; Mann, Alexander; Forni, John; Noakes, Catherine J.; Levine, Min Z.; Berman, LaShondra; Lindstrom, Stephen; Cauchemez, Simon; Bischoff, Werner; Tellier, Raymond; Milton, Donald K.; for the EMIT Consortium
Authors
Ben Killingley
Joanne Enstone
Michael Hewitt
Jovan Pantelic
Michael L. Grantham
P. Jacob Bueno de Mesquita
Robert Lambkin-Williams
Anthony Gilbert
Alexander Mann
John Forni
Catherine J. Noakes
Min Z. Levine
LaShondra Berman
Stephen Lindstrom
Simon Cauchemez
Werner Bischoff
Raymond Tellier
Donald K. Milton
for the EMIT Consortium
Contributors
Peter Palese
Editor
Abstract
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer ‘Donors’ (n = 52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). ‘Recipients’ randomized to Intervention (IR, n = 40) or Control (CR, n = 35) groups were exposed to Donors for four days. IRs wore face shields and hand sanitized frequently to limit large droplet and contact transmission. One transmitted infection was confirmed by serology in a CR, yielding a secondary attack rate of 2.9% among CR, 0% in IR (p = 0.47 for group difference), and 1.3% overall, significantly less than 16% (p [less than] 0.001) expected based on a proof-of-concept study secondary attack rate and considering that there were twice as many Donors and days of exposure. The main difference between these studies was mechanical building ventilation in the follow-on study, suggesting a possible role for aerosols.
Citation
Nguyen-Van-Tam, J. S., Killingley, B., Enstone, J., Hewitt, M., Pantelic, J., Grantham, M. L., …for the EMIT Consortium. (2020). Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment. PLoS Pathogens, 16(7), Article e1008704. https://doi.org/10.1371/journal.ppat.1008704
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 9, 2020 |
Online Publication Date | Jul 13, 2020 |
Publication Date | Jul 13, 2020 |
Deposit Date | Jul 18, 2020 |
Publicly Available Date | Jul 31, 2020 |
Journal | PLOS Pathogens |
Print ISSN | 1553-7366 |
Electronic ISSN | 1553-7374 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 16 |
Issue | 7 |
Article Number | e1008704 |
DOI | https://doi.org/10.1371/journal.ppat.1008704 |
Keywords | Immunology; Genetics; Molecular Biology; Microbiology; Parasitology; Virology |
Public URL | https://nottingham-repository.worktribe.com/output/4772628 |
Publisher URL | https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008704 |
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