Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas

Yang, Guang; O'Duill, Miriam; Gouverneur, Véronique; Krafft, Marie Pierre

Abstract

Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid-condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2F5-labeled molecule remains trapped in the monolayer after removal of F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2F5-labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers.

Citation

Yang, G., O'Duill, M., Gouverneur, V., & Krafft, M. P. (2015). Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas. Angewandte Chemie International Edition, 54(29), 8402-8406. https://doi.org/10.1002/anie.201502677

• Journal Article Type: Article
• Acceptance Date: Jun 9, 2015
• Online Publication Date: Jun 9, 2015
• Publication Date: Jul 13, 2015
• Deposit Date: Jun 29, 2020
• Journal: Angewandte Chemie - International Edition
• Print ISSN: 1433-7851
• Electronic ISSN: 1521-3773
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 54
• Issue: 29
• Pages: 8402-8406
• DOI: https://doi.org/10.1002/anie.201502677
• Public URL: https://nottingham-repository.worktribe.com/output/4711221
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201502677