The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison

Hemsworth, Jake; Vinogradov, Andrej; Lewis, William; Woodward, Simon; Willcox, Darren

Abstract

A simple one-pot reaction of LiAlH4, AlCl3, and a secondary amine HNR2 [R = Et, iPr, iBu, cyclo-C6H11, (CH2)4, and (CH2)5] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [H2Al(NR2)]n (n = 2 or 3) as crystalline solids (35–85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca. 5 min.) handling of [H2Al(NiPr2)]2 in air.

Citation

Hemsworth, J., Vinogradov, A., Lewis, W., Woodward, S., & Willcox, D. (2025). The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison. Molecules, 30(5), Article 986. https://doi.org/10.3390/molecules30050986

• Journal Article Type: Article
• Acceptance Date: Feb 18, 2025
• Online Publication Date: Feb 20, 2025
• Publication Date: Mar 1, 2025
• Deposit Date: Mar 6, 2025
• Publicly Available Date: Mar 6, 2025
• Journal: Molecules
• Electronic ISSN: 1420-3049
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 5
• Article Number: 986
• DOI: https://doi.org/10.3390/molecules30050986
• Public URL: https://nottingham-repository.worktribe.com/output/46191579
• Publisher URL: https://www.mdpi.com/1420-3049/30/5/986