12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study

Ting, Darren Shu Jeng; Ho, Charlotte S.; Cairns, Jessica; Elsahn, Ahmad; Al-Aqaba, Mouhamed A.; Boswell, Tim; Said, Dalia G.; Dua, Harminder

Abstract

Background/aims: To examine the incidence, causative microorganisms and in vitro antimicrobial susceptibility and resistance profiles of infectious keratitis (IK) in Nottingham, UK.

Methods: A retrospective study of all patients who were diagnosed with IK and underwent corneal scraping between July 2007 and October 2019 (a 12-year period) at a UK tertiary referral centre. Relevant data, including demographic factors, microbiological profiles and in vitro antibiotic susceptibility of IK, were analysed.

Results: The estimated incidence of IK was 34.7 per 100 000 people/year. Of the 1333 corneal scrapes, 502 (37.7%) were culture-positive and 572 causative microorganisms were identified. Sixty (4.5%) cases were of polymicrobial origin (caused by ≥2 different microorganisms). Gram-positive bacteria (308, 53.8%) were most commonly isolated, followed by Gram-negative bacteria (223, 39.0%), acanthamoeba (24, 4.2%) and fungi (17, 3.0%). Pseudomonas aeruginosa (135, 23.6%) was the single most common organism isolated. There was a significant increase in Moraxella spp (p

Citation

Ting, D. S. J., Ho, C. S., Cairns, J., Elsahn, A., Al-Aqaba, M. A., Boswell, T., Said, D. G., & Dua, H. (2021). 12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study. British Journal of Ophthalmology, 105(3), 328-333. https://doi.org/10.1136/bjophthalmol-2020-316128

• Journal Article Type: Article
• Acceptance Date: Apr 27, 2020
• Online Publication Date: Jun 24, 2020
• Publication Date: 2021-03
• Deposit Date: May 6, 2020
• Publicly Available Date: Jun 24, 2020
• Journal: British Journal of Ophthalmology
• Print ISSN: 0007-1161
• Electronic ISSN: 1468-2079
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 105
• Issue: 3
• Pages: 328-333
• DOI: https://doi.org/10.1136/bjophthalmol-2020-316128
• Public URL: https://nottingham-repository.worktribe.com/output/4385353
• Publisher URL: https://bjo.bmj.com/content/early/2020/06/24/bjophthalmol-2020-316128.full