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Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism

Bellato, Alessio; Arora, Iti; Kochhar, Puja; Hollis, Chris; Groom, Madeleine J.

Authors

Alessio Bellato

Iti Arora

PUJA KOCHHAR puja.kochhar@nottingham.ac.uk
Clinical Assistant Professor

CHRIS HOLLIS chris.hollis@nottingham.ac.uk
Professor of Child and Adolescent Psychiatry and Digital Mental Health



Abstract

Investigating electrophysiological measures during resting-state might be useful to investigate brain functioning and responsivity in individuals under diagnostic assessment for attention deficit hyperactivity disorder (ADHD) and autism. EEG was recorded in 43 children with or without ADHD and autism, during a 4-min-long resting-state session which included an eyes-closed and an eyes-open condition. We calculated and analyzed occipital absolute and relative spectral power in the alpha frequency band (8-12 Hz), and alpha reactivity, conceptualized as the difference in alpha power between eyes-closed and eyes-open conditions. Alpha power was increased during eyes-closed compared to eyes-open resting-state. While absolute alpha power was reduced in children with autism, relative alpha power was reduced in children with ADHD, especially during the eyes-closed condition. Reduced relative alpha reactivity was mainly associated with lower IQ and not with ADHD or autism. Atypical brain functioning during resting-state seems differently associated with ADHD and autism, however further studies replicating these results are needed; we therefore suggest involving research groups worldwide by creating a shared and publicly available repository of resting-state EEG data collected in people with different psychological, psychiatric, or neurodevelopmental conditions, including ADHD and autism.

Citation

Bellato, A., Arora, I., Kochhar, P., Hollis, C., & Groom, M. J. (2020). Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism. Brain Sciences, 10(5), 1-12. https://doi.org/10.3390/brainsci10050272

Journal Article Type Article
Acceptance Date Apr 24, 2020
Online Publication Date May 1, 2020
Publication Date May 1, 2020
Deposit Date May 1, 2020
Publicly Available Date Mar 29, 2024
Journal Brain Sciences
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 10
Issue 5
Article Number 272
Pages 1-12
DOI https://doi.org/10.3390/brainsci10050272
Keywords ADHD; autism; resting-state; EEG; alpha; alpha reactivity
Public URL https://nottingham-repository.worktribe.com/output/4370508
Publisher URL https://www.mdpi.com/2076-3425/10/5/272
Additional Information Bellato, A.; Arora, I.; Kochhar, P.; Hollis, C.; Groom, M.J. Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism. Brain Sci. 2020, 10, 272.