Hilmar P. Sigurdsson
A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation
Sigurdsson, Hilmar P.; Jackson, Georgina M.; Jackson, Stephen R.; Dyke, Katherine; Kim, Soyoung
Authors
GEORGINA JACKSON GEORGINA.JACKSON@NOTTINGHAM.AC.UK
Professor of Cognitive Neuropsychology
STEPHEN JACKSON stephen.jackson@nottingham.ac.uk
Professor of Cognitive Neuroscience
KATHERINE DYKE Katherine.Dyke@nottingham.ac.uk
Assistant Professor
Soyoung Kim
Abstract
Tourette syndrome (TS) is a hyperkinetic movement disorder characterised by the occurrence of chronic motor and vocal tics, and is associated with alterations in the balance of excitatory and inhibitory signalling within key brain networks; in particular the cortical-striatal-thalamic-cortical (CSTC) brain circuits that are implicated in movement selection and habit learning. Converging evidence indicates abnormal brain network function in TS may be largely due to the impaired operation of GABA signalling within the striatum and within cortical motor areas, leading to the occurrence of tics. TS has been linked to a heightened sensitivity to somatic stimulation and altered processing of somatosensory information, and there is evidence to indicate that alterations in GABAergic function is likely to contribute to altered somatomotor function. Based upon this evidence, we hypothesised that the specificity of somatomotor representations in primary motor cortex would likely be reduced in individuals with TS. To test this, we used a rapid acquisition method together with neuronavigated transcranial magnetic stimulation (nTMS) to measure the cortical representation of a several different muscles in a group of young adults with TS and a matched group of typically developing individuals.
Citation
Sigurdsson, H. P., Jackson, G. M., Jackson, S. R., Dyke, K., & Kim, S. (2020). A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation. Cortex, 129, 175-187. https://doi.org/10.1016/j.cortex.2020.04.014
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 21, 2020 |
Online Publication Date | May 4, 2020 |
Publication Date | 2020-08 |
Deposit Date | Apr 29, 2020 |
Publicly Available Date | May 5, 2021 |
Journal | Cortex |
Print ISSN | 0010-9452 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 129 |
Pages | 175-187 |
DOI | https://doi.org/10.1016/j.cortex.2020.04.014 |
Keywords | Experimental and Cognitive Psychology; Cognitive Neuroscience; Neuropsychology and Physiological Psychology |
Public URL | https://nottingham-repository.worktribe.com/output/4359036 |
Publisher URL | https://www.sciencedirect.com/science/article/abs/pii/S0010945220301581 |
Files
TS TMS Mapping MANUSCRIPT Accepted
(<nobr>971 Kb</nobr>)
PDF
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