A meta-analysis of remote ischaemic conditioning in experimental stroke

Weir, Philippa; Maguire, Ryan; O�Sullivan, Saoirse E.; England, Timothy J

Abstract

Remote ischaemic conditioning (RIC) is achieved by repeated transient ischaemia of a distant organ/limb and is neuroprotective in experimental ischaemic stroke. However, the optimal time and methods of administration are unclear. Systematic review identified relevant preclinical studies; two authors independently extracted data on infarct volume, neurological deficit, RIC method (administration time, site, cycle number, length of limb occlusion (dose)), species and quality. Data were analysed using random effects models; results expressed as standardised mean difference (SMD). In 57 publications incorporating 99 experiments (1406 rats, 101 mice, 14 monkeys), RIC reduced lesion volume in transient (SMD −2.0; 95% CI −2.38, −1.61; p 

Citation

Weir, P., Maguire, R., O’Sullivan, S. E., & England, T. J. (2021). A meta-analysis of remote ischaemic conditioning in experimental stroke. Journal of Cerebral Blood Flow and Metabolism, 41(1), 3-13. https://doi.org/10.1177/0271678x20924077

• Journal Article Type: Article
• Acceptance Date: Mar 30, 2020
• Online Publication Date: Jun 14, 2020
• Publication Date: 2021-01
• Deposit Date: Apr 3, 2020
• Publicly Available Date: Jun 14, 2020
• Journal: Journal of Cerebral Blood Flow & Metabolism
• Electronic ISSN: 0271-678X
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 41
• Issue: 1
• Pages: 3-13
• DOI: https://doi.org/10.1177/0271678x20924077
• Keywords: Neurology; Clinical Neurology; Cardiology and Cardiovascular Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/4247471
• Publisher URL: https://journals.sagepub.com/doi/abs/10.1177/0271678X20924077