Ivano Amelio
The “Sharp” blade against HIF-mediated metastasis
Amelio, Ivano; Melino, Gerry
Authors
Gerry Melino
Abstract
Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1α to the proteasome and promotes its O2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.
Citation
Amelio, I., & Melino, G. (2012). The “Sharp” blade against HIF-mediated metastasis. Cell Cycle, 11(24), 4530-4535. https://doi.org/10.4161/cc.22820
Journal Article Type | Article |
---|---|
Online Publication Date | Oct 31, 2014 |
Publication Date | Dec 15, 2012 |
Deposit Date | Apr 1, 2020 |
Journal | Cell Cycle |
Print ISSN | 1538-4101 |
Electronic ISSN | 1551-4005 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 24 |
Pages | 4530-4535 |
DOI | https://doi.org/10.4161/cc.22820 |
Keywords | HIF, Sharp1, hypoxia, metastasis, cancer metabolism, breast cancer, angiogenesis, VHL, p63 |
Public URL | https://nottingham-repository.worktribe.com/output/4237312 |
Publisher URL | https://www.tandfonline.com/doi/full/10.4161/cc.22820 |
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