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Exploring the Association between Vascular Dysfunction and Skeletal Muscle Mass, Strength and Function in Healthy Adults: A Systematic Review

Pereira, Suzette L.; Dvoretskiy, Svyatoslav; Phillips, Bethan E.; Lieblein-Boff, Jacqueline C.; Atherton, Philip J.; Jonnalagadda, Satya

Authors

Suzette L. Pereira

Svyatoslav Dvoretskiy

Jacqueline C. Lieblein-Boff

PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology

Satya Jonnalagadda



Abstract

Background: The prevalence of vascular dysfunction increases with advancing age, as does the loss of muscle mass, strength and function. This systematic review explores the association between vascular dysfunction and skeletal muscle health in healthy adults. Methods: EMBASE and MEDLINE were searched for cross-sectional and randomized controlled studies between January 2009 and April 2019, with 33 out of 1246 studies included based on predefined criteria. Assessments of muscular health included muscle mass, strength and function. Macrovascular function assessment included arterial stiffness (pulse wave velocity or augmentation index), carotid intima-media thickness, and flow-mediated dilation. Microvascular health assessment included capillary density or microvascular flow (contrast enhanced ultrasound). Results: All 33 studies demonstrated a significant association between vascular function and skeletal muscle health. Significant negative associations were reported between vascular dysfunction and -muscle strength (10 studies); -mass (9 studies); and -function (5 studies). Nine studies reported positive correlations between muscle mass and microvascular health. Conclusions: Multiple studies have revealed an association between vascular status and skeletal muscle health in healthy adults. This review points to the importance of screening for muscle health in adults with vascular dysfunction with a view to initiating early nutrition and exercise interventions to ameliorate functional decline over time

Citation

Pereira, S. L., Dvoretskiy, S., Phillips, B. E., Lieblein-Boff, J. C., Atherton, P. J., & Jonnalagadda, S. (2020). Exploring the Association between Vascular Dysfunction and Skeletal Muscle Mass, Strength and Function in Healthy Adults: A Systematic Review. Nutrients, 12(3), 715. https://doi.org/10.3390/nu12030715

Journal Article Type Article
Acceptance Date Mar 4, 2020
Online Publication Date Mar 7, 2020
Publication Date Mar 7, 2020
Deposit Date Mar 27, 2020
Publicly Available Date Mar 27, 2020
Journal Nutrients
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 3
Pages 715
DOI https://doi.org/10.3390/nu12030715
Keywords vascular dysfunction; skeletal muscle mass; healthy adults
Public URL https://nottingham-repository.worktribe.com/output/4209433
Publisher URL https://www.mdpi.com/2072-6643/12/3/715

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