Anchor carbon dots inside NH2-MIL-88B via ship-in-a-bottle strategy for dual signal enhancement in colorimetric-fluorescent sensors

Lu, Yuhao; Dong, Xiuxiu; Ji, Guanya; Wang, Xuejing; Wang, Tao; Tang, Chengshun; Ola, Oluwafunmilola; Duan, Hongwei; Liu, Qian; Niu, Qijian

Abstract

The increase in oxytetracycline (OTC) pollution has become a significant risk to ecological stability and human health because of excessive use. Therefore, developing a precise and reliable sensor for trace OTC detection is critical. In this work, a dual-mode sensor of colorimetric-fluorescent (CL-FL) with dual signal-on was developed for OTC detection. Firstly, a novel carbon dots encapsulating in cavities of MOFs composite (CDs@NH2-MIL-88B) was constructed by the ship-in-a-bottle approach, which enhanced peroxidase-like activity and fluorescent intensity. Further, combining with surface molecularly imprinted polymer (MIP), the dual-mode sensor was constructed to develop selectivity (CDs@NH2-MIL-88B@rMIP). Finally, the dual signal enhancement mechanism of the sensor comes from the interaction between OTC and identifying binding site involving strong hydrogen bonding and metal complexation from imprinted cavity and CDs@NH2-MIL-88B, respectively. The prepared sensor has a linear detection range of 1.00 × 10−9 - 1.00 × 10−5 M with the limit of detection (LOD) of 1.47 × 10−10 M for the CL mode and a detection range of 1.00 × 10−11 −1.00 × 10−7 M with the LOD of 1.84 × 10−12 M for the FL mode. Meanwhile, the sensor shows high sensitivity, accuracy and reliability in OTC detection. Overall, this work provides a promising CL-FL dual-mode sensing systems with signal-on in the detection of antibiotics and other hazardous pollutants.

Citation

Lu, Y., Dong, X., Ji, G., Wang, X., Wang, T., Tang, C., Ola, O., Duan, H., Liu, Q., & Niu, Q. (2025). Anchor carbon dots inside NH2-MIL-88B via ship-in-a-bottle strategy for dual signal enhancement in colorimetric-fluorescent sensors. Sensors and Actuators B: Chemical, 424, Article 136877. https://doi.org/10.1016/j.snb.2024.136877

• Journal Article Type: Article
• Acceptance Date: Oct 30, 2024
• Online Publication Date: Nov 2, 2024
• Publication Date: Feb 1, 2025
• Deposit Date: Nov 7, 2024
• Publicly Available Date: Nov 3, 2025
• Journal: Sensors and Actuators B: Chemical
• Print ISSN: 0925-4005
• Electronic ISSN: 1873-3077
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 424
• Article Number: 136877
• DOI: https://doi.org/10.1016/j.snb.2024.136877
• Keywords: Metal-organic frameworks; CDs; Dual-mode sensor; Colorimetric- fluorescent; Dual signal-on; Oxytetracycline
• Public URL: https://nottingham-repository.worktribe.com/output/41551630
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0925400524016071?via%3Dihub