Anchor Carbon Dots Inside Nh2-Mil-88b Via Ship-in-A-Bottle Strategy for Dual Signal Enhancement in Colourimetric Fluorescent Sensors

Lu, Yuhao; Dong, Xiuxiu; Ji, Guanya; Wang, Xuejing; Wang, Tao; Tang, Chengshun; Ola, Oluwafunmilola; Duan, Hongwei; Liu, Qian; Niu, Qijian

Abstract

The increase in oxytetracycline (OTC) pollution has become a significant risk to both ecological stability and human health because of excessive use. Therefore, developing a precise and reliable sensor for detecting trace amounts of OTC is critical. In this work, a dual-mode sensor with ‘turn on’ signals of colourimetric-fluorescent was developed for OTC detection. First, a novel CDs@NH2-MIL-88B was constructed using the ‘ship-in-a-bottle’ approach, which enhanced peroxidase-like activity and fluorescent intensity. Furthermore, combined with surface molecular imprinting technology, the CDs@NH2-MIL-88B@rMIP was constructed to develop selectivity. Finally, peroxidase-like activity and fluorescence intensity enhancements were achieved by identifying the binding site involving strong hydrogen bonding and metal complexation from the imprinted cavity and NH2-MIL-88B, respectively. The resulting dual-mode sensor has a linear detection range of 1.00 × 10-9 - 1.00 × 10-5 M with a detection limit of 1.47 × 10-10 M for the colourimetric mode and a detection range of 1.00 × 10-11 − 1.00 × 10-7 M with a detection limit of 1.84 × 10-12 M for the fluorescent mode. Meanwhile, the sensor shows high sensitivity, accuracy and reliability in OTC detection of actual samples. Overall, this dual-mode sensor offers a new and effective method for OTC detection in practical applications.

Citation

Lu, Y., Dong, X., Ji, G., Wang, X., Wang, T., Tang, C., Ola, O., Duan, H., Liu, Q., & Niu, Q. Anchor Carbon Dots Inside Nh2-Mil-88b Via Ship-in-A-Bottle Strategy for Dual Signal Enhancement in Colourimetric Fluorescent Sensors

• Working Paper Type: Preprint
• Deposit Date: Sep 25, 2024
• Publicly Available Date: Sep 27, 2024
• DOI: https://doi.org/10.2139/ssrn.4963530
• Keywords: Metal-organic frameworks, CDs, dual-mode sensor, signal 'turn on', oxytetracycline
• Public URL: https://nottingham-repository.worktribe.com/output/39990459
• Publisher URL: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4963530