The effect of maternal dietary fat content and omega-6 to omega-3 ratio on offspring growth and hepatic gene expression in the rat

Draycott, Sally A.V.; George, Grace; Elmes, Matthew J.; Muhlhausler, Beverly S.; Langley-Evans, Simon C.

Abstract

© The Authors 2020. Omega-6 fatty acids have been shown to exert pro-adipogenic effects whereas omega-3 fatty acids work in opposition. Increasing intakes of LA (linoleic acid; omega-6) vs ALA (alpha-linolenic acid; omega-3) in Western diets has led to the hypothesis that consumption of this diet during pregnancy may be contributing to adverse offspring health. This study investigated the effects of feeding a maternal dietary LA:ALA ratio similar to that of the Western diet (9:1) compared to a proposed 'ideal' ratio (∼1:1.5), at two total fat levels (18% vs 36% fat w/w), on growth and lipogenic gene expression in the offspring. Female Wistar rats were assigned to one of the four experimental groups throughout gestation and lactation. Offspring were culled at 1 and 2 weeks of age for sample collection. Offspring of dams consuming a -36% fat diet were ∼20% lighter than those exposed to a 18% fat diet (P

Citation

Draycott, S. A., George, G., Elmes, M. J., Muhlhausler, B. S., & Langley-Evans, S. C. (2020). The effect of maternal dietary fat content and omega-6 to omega-3 ratio on offspring growth and hepatic gene expression in the rat. British Journal of Nutrition, 123(11), 1227-1238. https://doi.org/10.1017/S000711452000046X

• Journal Article Type: Article
• Acceptance Date: Feb 7, 2020
• Online Publication Date: Feb 13, 2020
• Publication Date: Jun 14, 2020
• Deposit Date: Feb 10, 2020
• Publicly Available Date: Aug 14, 2020
• Journal: British Journal of Nutrition
• Print ISSN: 0007-1145
• Electronic ISSN: 1475-2662
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 123
• Issue: 11
• Pages: 1227-1238
• DOI: https://doi.org/10.1017/S000711452000046X
• Keywords: Maternal nutrition; Omega; Pregnancy; Growth restriction Subject Category: Molecular Nutrition Cambridge University Press British Journal of Nutrition
• Public URL: https://nottingham-repository.worktribe.com/output/3938841
• Publisher URL: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-maternal-dietary-fat-content-and-omega6-to-omega3-ratio-on-offspring-growth-and-hepatic-gene-expression-in-the-rat/7054780896C20689E8EE9275CC927741