The role of node dynamics in shaping emergent functional connectivity patterns in the brain

Forrester, M.; Crofts, J. J.; Sotiropoulos, S.N.; Coombes, S.; O�Dea, R.D.

Abstract

The contribution of structural connectivity to functional brain states remains poorly understood. We present a mathematical and computational study suited to assess the structure–function issue, treating a system of Jansen–Rit neural-mass nodes with heterogeneous structural connections estimated from diffusion MRI data provided by the Human Connectome Project. Via direct simulations we determine the similarity of functional (inferred from correlated activity between nodes) and structural connectivity matrices under variation of the parameters controlling single-node dynamics, highlighting a non-trivial structure–function relationship in regimes that support limit cycle oscillations. To determine their relationship, we firstly calculate network instabilities giving rise to oscillations, and the so-called ‘false bifurcations’ (for which a significant qualitative change in the orbit is observed, without a change of stability) occurring beyond this onset. We highlight that functional connectivity (FC) is inherited robustly from structure when node dynamics are poised near a Hopf bifurcation, whilst near false bifurcations, structure only weakly influences FC. Secondly, we develop a weakly-coupled oscillator description to analyse oscillatory phase-locked states and, furthermore, show how the modular structure of FC matrices can be predicted via linear stability analysis. This study thereby emphasises the substantial role that local dynamics can have in shaping large-scale functional brain states.

Citation

Forrester, M., Crofts, J. J., Sotiropoulos, S., Coombes, S., & O’Dea, R. (2020). The role of node dynamics in shaping emergent functional connectivity patterns in the brain. Network Neuroscience, 4(2), 467-483. https://doi.org/10.1162/netn_a_00130

• Journal Article Type: Article
• Acceptance Date: Jan 28, 2020
• Online Publication Date: Feb 3, 2020
• Publication Date: Feb 3, 2020
• Deposit Date: Feb 11, 2020
• Publicly Available Date: Jun 4, 2020
• Journal: Network Neuroscience
• Electronic ISSN: 2472-1751
• Publisher: Massachusetts Institute of Technology Press
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 2
• Pages: 467-483
• DOI: https://doi.org/10.1162/netn_a_00130
• Keywords: Structural connectivity, functional connectivity, neural mass model, coupled oscillator theory, Hopf bifurcation, false bifurcation
• Public URL: https://nottingham-repository.worktribe.com/output/3918766
• Publisher URL: https://www.mitpressjournals.org/doi/abs/10.1162/netn_a_00130
• Additional Information: Received: 2019-07-02; Accepted: 2020-01-31; Published: 2020-02-03