Neurobehavioural characterisation and stratification of reinforcement-related behaviour

Jia, Tianye; Ing, Alex; Burke Quinlan, Erin; Tay, Nicole; Luo, Qiang; Francesca, Biondo; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; B�chel, Christian; Desrivi�res, Sylvane; Feng, Jianfeng; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paill�re Martinot, Marie-Laure; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tom�; Poustka, Luise; Fr�hner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter

Abstract

Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes, and if neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed co-morbidity.

Citation

Jia, T., Ing, A., Burke Quinlan, E., Tay, N., Luo, Q., Francesca, B., …Schumann, G. (2020). Neurobehavioural characterisation and stratification of reinforcement-related behaviour. Nature Human Behaviour, 4, 544–558. https://doi.org/10.1038/s41562-020-0846-5

• Journal Article Type: Article
• Acceptance Date: Jan 26, 2020
• Online Publication Date: Apr 20, 2020
• Publication Date: 2020-05
• Deposit Date: Jan 26, 2020
• Publicly Available Date: Oct 21, 2020
• Journal: Nature Human Behaviour
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Pages: 544–558
• DOI: https://doi.org/10.1038/s41562-020-0846-5
• Public URL: https://nottingham-repository.worktribe.com/output/3807641
• Publisher URL: https://www.nature.com/articles/s41562-020-0846-5
• Additional Information: Received: 7 March 2019; Accepted: 28 February 2020; First Online: 20 April 2020; : T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg and Shire. He received conference support or speaker’s fees from Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire and Vifor Pharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to the above grants and relationships. G.J.B. has received honoraria from General Electric Healthcare for teaching on scanner programming courses. The other authors declare no competing interests.