Quantitative BOLD (qBOLD) imaging of oxygen metabolism and blood oxygenation in the human body: A scoping review

Alzaidi, Ahlam A.; Panek, Rafal; Blockley, Nicholas P.

Abstract

Purpose
There are many approaches to the quantitative BOLD (qBOLD) technique described in the literature, differing in pulse sequences, MRI parameters and data processing. Thus, in this review, we summarized the acquisition methods, approaches used for oxygenation quantification and clinical populations investigated.

Methods
Three databases were systematically searched (Medline, Embase, and Web of Science) for published research that used qBOLD methods for quantification of oxygen metabolism. Data extraction and synthesis were performed by one author and reviewed by a second author.

Results
A total of 93 relevant papers were identified. Acquisition strategies were summarized, and oxygenation parameters were found to have been investigated in many pathologies such as steno-occlusive diseases, stroke, glioma, and multiple sclerosis disease.

Conclusion
A summary of qBOLD approaches for oxygenation measurements and applications could help researchers to identify good practice and provide objective information to inform the development of future consensus recommendations.

Citation

Alzaidi, A. A., Panek, R., & Blockley, N. P. (2024). Quantitative BOLD (qBOLD) imaging of oxygen metabolism and blood oxygenation in the human body: A scoping review. Magnetic Resonance in Medicine, https://doi.org/10.1002/mrm.30165

• Journal Article Type: Review
• Acceptance Date: May 8, 2024
• Online Publication Date: Jul 28, 2024
• Publication Date: Jul 28, 2024
• Deposit Date: Aug 9, 2024
• Publicly Available Date: Aug 20, 2024
• Journal: Magnetic Resonance in Medicine
• Print ISSN: 0740-3194
• Electronic ISSN: 1522-2594
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/mrm.30165
• Public URL: https://nottingham-repository.worktribe.com/output/37949827
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/mrm.30165