GEORGE GORDON GEORGE.GORDON@NOTTINGHAM.AC.UK
Associate Professor
Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis
Gordon, George S. D.; Joseph, James; Alcolea, Maria P.; Sawyer, Travis; Williams, Calum; Fitzpatrick, Catherine R. M.; Jones, Philip H.; Di Pietro, Massimiliano; Fitzgerald, Rebecca C.; Wilkinson, Timothy D.; Bohndiek, Sarah E.
Authors
James Joseph
Maria P. Alcolea
Travis Sawyer
Calum Williams
Catherine R. M. Fitzpatrick
Philip H. Jones
Massimiliano Di Pietro
Rebecca C. Fitzgerald
Timothy D. Wilkinson
Sarah E. Bohndiek
Abstract
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Phase and polarization of coherent light are highly perturbed by interaction with microstructural changes in premalignant tissue, holding promise for label-free detection of early tumors in endoscopically accessible tissues such as the gastrointestinal tract. Flexible optical multicore fiber (MCF) bundles used in conventional diagnostic endoscopy and endomicroscopy scramble phase and polarization, restricting clinicians instead to low-contrast amplitude-only imaging. We apply a transmission matrix characterization approach to produce full-field en-face images of amplitude, quantitative phase, and resolved polarimetric properties through an MCF. We first demonstrate imaging and quantification of biologically relevant amounts of optical scattering and birefringence in tissue-mimicking phantoms. We present an entropy metric that enables imaging of phase heterogeneity, indicative of disordered tissue microstructure associated with early tumors. Finally, we demonstrate that the spatial distribution of phase and polarization information enables label-free visualization of early tumors in esophageal mouse tissues, which are not identifiable using conventional amplitude-only information.
Citation
Gordon, G. S. D., Joseph, J., Alcolea, M. P., Sawyer, T., Williams, C., Fitzpatrick, C. R. M., …Bohndiek, S. E. (2019). Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis. Journal of Biomedical Optics, 24(12), Article 126004. https://doi.org/10.1117/1.JBO.24.12.126004
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 18, 2019 |
Online Publication Date | Dec 16, 2019 |
Publication Date | Dec 16, 2019 |
Deposit Date | Jan 22, 2020 |
Publicly Available Date | Mar 29, 2024 |
Journal | Journal of Biomedical Optics |
Print ISSN | 1083-3668 |
Electronic ISSN | 1560-2281 |
Publisher | Society of Photo-optical Instrumentation Engineers |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 12 |
Article Number | 126004 |
DOI | https://doi.org/10.1117/1.JBO.24.12.126004 |
Keywords | Atomic and Molecular Physics, and Optics; Electronic, Optical and Magnetic Materials; Biomaterials; Biomedical Engineering |
Public URL | https://nottingham-repository.worktribe.com/output/3780941 |
Publisher URL | https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-24/issue-12/126004/Quantitative-phase-and-polarization-imaging-through-an-optical-fiber-applied/10.1117/1.JBO.24.12.126004.full?SSO=1 |
Files
Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis
(7.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Air filtration mitigates aerosol levels both during and after endoscopy procedures
(2023)
Journal Article
Spectrally tailored hyperpixel filter arrays for efficient imaging of chemical compositions
(2022)
Journal Article
Transfering ultra-Thin metallic metasurfaces to fibre endoscope probes for advanced imaging
(2022)
Conference Proceeding
Polarization-Insensitive Medium-Switchable Holographic Metasurfaces
(2021)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search