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Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study

Nakafero, Georgina; Grainge, Matthew J.; Card, Tim; Mallen, Christian D.; Nguyen Van-Tam, Jonathan S.; Abhishek, Abhishek

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study Thumbnail


Authors

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

Christian D. Mallen

Jonathan S. Nguyen Van-Tam



Abstract

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.

Design Data for adults with IBD diagnosed before the 1 September 2018 were extracted from the Clinical Practice Research Datalink Gold. We calculated the proportion of people vaccinated against seasonal influenza in the 2018–2019 influenza cycle. To investigate vaccine effectiveness, we calculated the propensity score (PS) for vaccination and conducted Cox proportional hazard regression with inverse-probability treatment weighting on PS. We employed self-controlled case series analysis to investigate the association between vaccination and IBD flare.

Results Data for 13 631 people with IBD (50.4% male, mean age 52.9 years) were included. Fifty percent were vaccinated during the influenza cycle, while 32.1% were vaccinated on time, that is, before the seasonal influenza virus circulated in the community. IIV was associated with reduced all-cause mortality (aHR (95% CI): 0.73 (0.55,0.97) but not hospitalisation for pneumonia (aHR (95% CI) 0.52 (0.20–1.37), including in the influenza active period (aHR (95% CI) 0.48 (0.18–1.27)). Administration of the IIV was not associated with IBD flare.

Conclusion The uptake of influenza vaccine was low in people with IBD, and the majority were not vaccinated before influenza virus circulated in the community. Vaccination with the IIV was not associated with IBD flare. These findings add to the evidence to promote vaccination against influenza in people with IBD.

Citation

Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Journal Article Type Article
Acceptance Date May 26, 2024
Online Publication Date Jun 18, 2024
Publication Date Jun 18, 2024
Deposit Date Jun 22, 2024
Publicly Available Date Jun 24, 2024
Journal BMJ Open Gastroenterology
Electronic ISSN 2054-4774
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Article Number e001370
DOI https://doi.org/10.1136/bmjgast-2024-001370
Public URL https://nottingham-repository.worktribe.com/output/36307292
Publisher URL https://bmjopengastro.bmj.com/content/11/1/e001370

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