Craniectomy with soft tissue reconstruction for locally advanced non-melanoma skin cancer of scalp with calvarial invasion: The Nottingham experience

Wong, Zhen Y.; Wickham, Neil; Bagirathan, Shenbana; Leggate, Alex; Smith, Stuart J.; Pollock, Jonathan

Abstract

Introduction: Locally advanced non-melanoma skin cancer (NMSC) involving the periosteum or calvarium poses a clinical challenge for patients who are unfit for immunotherapy due to medical comorbidities and/or frailty. This case series aims to investigate outcomes for patients undergoing craniectomy and soft tissue reconstruction. Method: Patients who underwent craniectomy and soft tissue reconstruction for invasive NMSC with calvarium or periosteal invasion between 2016 and 2022 were included. Data, including demographics, operative details, and clinical outcomes, were gathered from Nottingham University Hospitals’ digital health record and the histopathology electronic database. Result: Eight patients (average age: 78.4 years, 3 females 5 males) with significant comorbidities and varying degrees of periosteal or bone invasion fulfilled the inclusion criteria. Diagnoses included four squamous cell carcinomas, two basal cell carcinomas, and two pleomorphic dermal sarcomas. Five patients had a history of prior incomplete deep margin excision. The median sizes for soft tissue defect, tumor and bone defect size were 51.83 cm2, 34.63 cm2 and 42.25 cm2, respectively. Intraoperative complications included one dural tear. Four patients underwent local flap reconstruction and with split-thickness skin grafting, four patients underwent free flap reconstruction. Adjuvant radiotherapy was administered to three patients. Complications comprised partial graft loss in two and complete graft loss in one. There was partial flap loss in one case. One patient required subsequent parotidectomy due to regional progression before achieving disease control. All patients achieved lasting locoregional disease control (average follow-up 29.7 months). Conclusion: Craniectomy with soft tissue reconstruction proves to be a safe and effective treatment option in advanced NMSC of the scalp in patients unsuitable for immunotherapy due to frailty or medical co-morbidity.

• Journal Article Type: Article
• Acceptance Date: Feb 1, 2024
• Online Publication Date: Feb 6, 2024
• Publication Date: 2024-03
• Deposit Date: Mar 12, 2024
• Publicly Available Date: Feb 7, 2025
• Journal: Journal of Plastic, Reconstructive and Aesthetic Surgery
• Print ISSN: 1748-6815
• Electronic ISSN: 1878-0539
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 90
• Pages: 175-182
• DOI: https://doi.org/10.1016/j.bjps.2024.02.016
• Keywords: Free flap reconstruction of the calvarium; Microsurgical reconstruction; Non-melanoma skin cancers of the scalp
• Public URL: https://nottingham-repository.worktribe.com/output/32457557
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1748681524000780