Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes

Walmsley, John; Mirams, Gary; Bahoshy, Maya; Bollensdorff, Christian; Rodriguez, Blanca; Burrage, Kevin

Abstract

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beatto- beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells originating from the same region of the same heart. However, current mathematical models of ventricular AP fail to replicate the temporal and cell-to-cell variability in AP observed experimentally. In this study, we propose a novel mathematical framework for the development of phenomenological AP models capable of capturing cell-to-cell and temporal variabilty in cardiac APs. A novel stochastic phenomenological model of the AP is developed, based on the deterministic Bueno- Orovio/Fenton model. Experimental recordings of AP are fit to the model to produce AP models of individual cells from the apex and the base of the guinea-pig ventricles. Our results show that the phenomenological model is able to capture the considerable differences in AP recorded from isolated cells originating from the location. We demonstrate the closeness of fit to the available experimental data which may be achieved using a phenomenological model, and also demonstrate the ability of the stochastic form of the model to capture the observed beat-to-beat variablity in action potential duration. © 2010 IEEE.

Citation

Walmsley, J., Mirams, G., Bahoshy, M., Bollensdorff, C., Rodriguez, B., & Burrage, K. (2010, August). Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. Presented at 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina

• Presentation Conference Type: Conference Paper (published)
• Conference Name: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
• Start Date: Aug 31, 2010
• End Date: Sep 4, 2010
• Online Publication Date: Nov 11, 2010
• Publication Date: Dec 1, 2010
• Deposit Date: Jan 14, 2020
• Publisher: Institute of Electrical and Electronics Engineers
• Pages: 1457-1460
• Book Title: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
• DOI: https://doi.org/10.1109/IEMBS.2010.5626858
• Public URL: https://nottingham-repository.worktribe.com/output/3217724
• Publisher URL: https://ieeexplore.ieee.org/document/5626858