Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications

Arjuna, Andi; Milborne, Ben; Putra, Amal Rezka; Mulyaningsih, Theresia Rina; Setiawan, Herlan; Islam, Md Towhidul; Felfel, Reda; Ahmed, Ifty

Abstract

Internal radiotherapy delivers radioactive sources inside the body, near to or into malignant tumours, which may be particularly effective when malignancies are not responding to external beam radiotherapy. A pure beta emitter, 90Y, is currently used for internal radiotherapy. However, theranostic radionuclide-doped microspheres can be developed by incorporating 153Sm, which emits therapeutic beta and diagnostic gamma energies. This study investigated the production of high concentrations of samarium-content doped phosphate-based glass microspheres. The glass P60 (i.e. 60P2O5-25CaO-15Na2O) was mixed with Sm2O3 at ratios of 75:25 (G75:Sm25), 50:50 (G50:Sm50) and 25:75 (G25:Sm75) and processed via flame spheroidisation. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) confirmed the microsphere uniformity with significantly high samarium content up to 44 % in G25:Sm75. Via X-ray diffraction (XRD) analysis, samarium-doped microspheres appeared to be glass–ceramic in nature. Mass-loss, size and pH changes were performed over 28 days, revealing a significant increase in samarium microsphere stability. After 15 min of neutron activation (neutron flux 3.01 × 1013 n.cm−2.s−1), the specific activity of the microspheres (G75:Sm25, G50:Sm50 and G25:Sm75) was 0.28, 0.54 and 0.58 GBq.g−1, respectively. Therefore, the samarium microspheres produced in this study provide great potential for improving internal radiotherapy treatment for liver cancer by avoiding complex procedures and using less microspheres with shorter irradiation time.

Citation

Arjuna, A., Milborne, B., Putra, A. R., Mulyaningsih, T. R., Setiawan, H., Islam, M. T., Felfel, R., & Ahmed, I. (2024). Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications. International Journal of Pharmaceutics, 653, Article 123919. https://doi.org/10.1016/j.ijpharm.2024.123919

• Journal Article Type: Article
• Acceptance Date: Feb 16, 2024
• Online Publication Date: Feb 17, 2024
• Publication Date: Mar 25, 2024
• Deposit Date: Feb 29, 2024
• Publicly Available Date: Feb 18, 2025
• Journal: International Journal of Pharmaceutics
• Print ISSN: 0378-5173
• Electronic ISSN: 1873-3476
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 653
• Article Number: 123919
• DOI: https://doi.org/10.1016/j.ijpharm.2024.123919
• Keywords: Internal radiotherapy, Flame spheroidisation, Microspheres, Samarium-doped phosphate glass
• Public URL: https://nottingham-repository.worktribe.com/output/31892841
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0378517324001534