The Hypoglycemic Effect of Pumpkin Seeds, Trigonelline (TRG), Nicotinic Acid (NA), and D-Chiro-inositol (DCI) in Controlling Glycemic Levels in Diabetes Mellitus

Adams, Gary G.; Imran, Shahwar; Wang, Sheng; Mohammad, Abubaker; Kok, M. Samil; Gray, David A.; Channell, Guy A.; Harding, Stephen E.

Abstract

In the contemporary society, diabetes mellitus is considered as a common, growing, serious, costly, and potentially preventable public health problem. It is forecasted that in 2030, the number of people with diabetes will go up from 117 million in 2000 to 366 million in 2030. The prevalence of diabetes will place a huge burden on health and financial structures of countries, and these will impact on individuals, as well as families and nations. Polysaccharides, para-aminobenzoic acid, fixed oils, sterol, proteins, and peptides are biologically active ingredients, which are found in pumpkins. The chemicals within pumpkins such as the fruit pulp, oil from ungerminated seeds, and protein from germinated seeds have hypoglycemic properties. Preliminary investigation showed that pumpkin seeds, and the macromolecules, therein, such as Trigonelline (TRG), Nicotinic acid (NA), and dchiro-inositol (DCI), possess hypoglycemic properties and could assist in maintaining glycemic control. © 2014 Copyright Taylor and Francis Group, LLC.

Citation

Adams, G. G., Imran, S., Wang, S., Mohammad, A., Kok, M. S., Gray, D. A., Channell, G. A., & Harding, S. E. (2014). The Hypoglycemic Effect of Pumpkin Seeds, Trigonelline (TRG), Nicotinic Acid (NA), and D-Chiro-inositol (DCI) in Controlling Glycemic Levels in Diabetes Mellitus. Critical Reviews in Food Science and Nutrition, 54(10), 1322-1329. https://doi.org/10.1080/10408398.2011.635816

• Journal Article Type: Article
• Online Publication Date: Feb 24, 2014
• Publication Date: Jan 1, 2014
• Deposit Date: Feb 25, 2025
• Journal: Critical Reviews in Food Science and Nutrition
• Print ISSN: 1040-8398
• Electronic ISSN: 1549-7852
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 54
• Issue: 10
• Pages: 1322-1329
• DOI: https://doi.org/10.1080/10408398.2011.635816
• Keywords: hypoglycemia, pumpkin seeds, trigonelline, nicotinic acid, d-chiroinositol
• Public URL: https://nottingham-repository.worktribe.com/output/3152684
• Publisher URL: https://www.tandfonline.com/doi/full/10.1080/10408398.2011.635816?scroll=top&needAccess=true
• Additional Information: Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=bfsn20