Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes

Raniga, Kavita; Nasir, Aishah; Vo, Nguyen T.N.; Vaidyanathan, Ravi; Dickerson, Sarah; Hilcove, Simon; Mosqueira, Diogo; Mirams, Gary R.; Clements, Peter; Hicks, Ryan; Pointon, Amy; Stebbeds, Will; Francis, Jo; Denning, Chris

Abstract

Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have prompted their therapeutic application and utilization for evaluating potential cardiovascular safety liabilities. In this perspective, we showcase key efforts toward the large-scale production of hiPSC-CMs, implementation of hiPSC-CMs in industry settings, and recent clinical applications of this technology. The key observations are a need for traceable gender and ethnically diverse hiPSC lines, approaches to reduce cost of scale-up, accessible clinical trial datasets, and transparent guidelines surrounding the safety and efficacy of hiPSC-based therapies.

Citation

Raniga, K., Nasir, A., Vo, N. T., Vaidyanathan, R., Dickerson, S., Hilcove, S., Mosqueira, D., Mirams, G. R., Clements, P., Hicks, R., Pointon, A., Stebbeds, W., Francis, J., & Denning, C. (2024). Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell, 31(3), 292-311. https://doi.org/10.1016/j.stem.2024.01.007

• Journal Article Type: Article
• Acceptance Date: Dec 21, 2023
• Online Publication Date: Feb 15, 2024
• Publication Date: Mar 7, 2024
• Deposit Date: Jul 29, 2024
• Publicly Available Date: Jul 30, 2024
• Journal: Cell Stem Cell
• Print ISSN: 1934-5909
• Electronic ISSN: 1875-9777
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 3
• Pages: 292-311
• DOI: https://doi.org/10.1016/j.stem.2024.01.007
• Keywords: Cell Biology; Genetics; Molecular Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/31453013
• Publisher URL: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00008-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590924000080%3Fshowall%3Dtrue