In Situ Sulfidation of Pd/C: A Straightforward Method for Chemoselective Conjugate Reduction by Continuous Hydrogenation

Moore, Jonathan C.; Howie, Rowena A.; Bourne, Samuel L.; Jenkins, Gareth N.; Licence, Peter; Poliakoff, Martyn; George, Michael W.

Abstract

A method has been developed for the in situ sulfidation of Pd/C under continuous flow. The approach provides a cheap, sustainable, and operationally convenient method for chemoselective conjugate reduction by continuous hydrogenation. High conversions and excellent selectivities were obtained for olefin reduction in ?/?-unsaturated carbonyl compounds in the presence of hydrogenatively sensitive functionalities. The methodology was analyzed with a green metric system to highlight the sustainability features of the process.

• Journal Article Type: Article
• Acceptance Date: Sep 11, 2019
• Online Publication Date: Sep 25, 2019
• Publication Date: Oct 7, 2019
• Deposit Date: Oct 28, 2019
• Publicly Available Date: Sep 26, 2020
• Journal: ACS Sustainable Chemistry & Engineering
• Electronic ISSN: 2168-0485
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 19
• Pages: 16814-16819
• DOI: https://doi.org/10.1021/acssuschemeng.9b04347
• Public URL: https://nottingham-repository.worktribe.com/output/2977111
• Publisher URL: https://pubs.acs.org/doi/10.1021/acssuschemeng.9b04347