New concepts in C. difficile management

Mahida, Y.R.

Abstract

Background
Clostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and clinical presentation can range from asymptomatic carriage to life-threatening pseudomembranous colitis.

Sources of data
publications in the field, with a focus on recent developments and concepts.

Areas of agreement
infection control measures, antibiotic stewardship and current management of the initial episode of C. difficile infection.

Areas of controversy
selection and sequence of interventions for the management of recurrent C. difficile infection; management of persistent carriers of toxigenic C. difficile in patients at high risk of subsequent C. difficile infection.

Growing points
use of faecal microbiota transplantation for recurrent C. difficile infection.

Areas timely for developing research
role of specific microbiota-mediated interventions and vaccination in the treatment and prevention of C. difficile infection.

Citation

Mahida, Y. (2019). New concepts in C. difficile management. British Medical Bulletin, 131(1), 109–118. https://doi.org/10.1093/bmb/ldz029

• Journal Article Type: Article
• Acceptance Date: Aug 8, 2019
• Online Publication Date: Oct 4, 2019
• Publication Date: Sep 30, 2019
• Deposit Date: Oct 10, 2019
• Publicly Available Date: Oct 1, 2020
• Journal: British Medical Bulletin
• Print ISSN: 0007-1420
• Electronic ISSN: 1471-8391
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 131
• Issue: 1
• Pages: 109–118
• DOI: https://doi.org/10.1093/bmb/ldz029
• Public URL: https://nottingham-repository.worktribe.com/output/2795715
• Publisher URL: https://academic.oup.com/bmb/advance-article/doi/10.1093/bmb/ldz029/5580530
• Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in British Medical Bulletin following peer review. The version of record Y R Mahida, New concepts in C. difficile management, British Medical Bulletin, , ldz029, is available online at: https://academic.oup.com/bmb/advance-article/doi/10.1093/bmb/ldz029/5580530