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Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients

Mohammed, Rabab Ahmed A.; El-Deek, Heba El-Deek Mohammed; El-Deek, Mohammed; Aleskandarany, Mohammad A.; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.

Authors

Rabab Ahmed A. Mohammed

Heba El-Deek Mohammed El-Deek

Mohammed El-Deek

Andrew R. Green

Emad A. Rakha



Abstract

Background and aims: Clinicopathological features of Basal-like Breast Cancer (BLBC) in African American women have been extensively studied. Comparatively, less is known about these tumors in patients from countries in the North African region. The aim of this study was to assess the frequency and clinicopathological characteristics of BLBC in Egyptian patients with comparison to British patients. Material and methods: Tissue microarray blocks were constructed from primary invasive breast cancer from 321 Egyptian and 527 British BC patients. Sections were stained immunohistochemically with oestrogen receptor (ER), progesterone receptor (PR), HER2, CK19, CK14, EGFR, CK5/6, P53 and Ki67. BLBC phenotype was identified by lacking of staining of ER, PR, HER2 and positive staining for any of the CK14, CK5/6 and/or EGFR. Results: The rate of BLBC phenotype was higher in Egyptian cohort (21%) than the British cohort (13%). BLBC tumors from both Egyptian and British patients were significantly associated with tumors of higher histopathological grade (P

Journal Article Type Article
Journal Egyptian Journal of Pathology
Electronic ISSN 2090-5378
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Institution Citation Mohammed, R. A. A., El-Deek, H. E. M., Aleskandarany, M. A., Green, A. R., Ellis, I. O., & Rakha, E. A. (in press). Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients. Egyptian Journal of Pathology,