Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients

Mohammed, Rabab Ahmed A.; El-Deek, Heba El-Deek Mohammed; Aleskandarany, Mohammad A.; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.

Abstract

Background and aims: Clinicopathological features of Basal-like Breast Cancer (BLBC) in African American women have been extensively studied. Comparatively, less is known about these tumors in patients from countries in the North African region. The aim of this study was to assess the frequency and clinicopathological characteristics of BLBC in Egyptian patients with comparison to British patients. Material and methods: Tissue microarray blocks were constructed from primary invasive breast cancer from 321 Egyptian and 527 British BC patients. Sections were stained immunohistochemically with oestrogen receptor (ER), progesterone receptor (PR), HER2, CK19, CK14, EGFR, CK5/6, P53 and Ki67. BLBC phenotype was identified by lacking of staining of ER, PR, HER2 and positive staining for any of the CK14, CK5/6 and/or EGFR. Results: The rate of BLBC phenotype was higher in Egyptian cohort (21%) than the British cohort (13%). BLBC tumors from both Egyptian and British patients were significantly associated with tumors of higher histopathological grade (P

Citation

Mohammed, R. A. A., El-Deek, H. E. M., Aleskandarany, M. A., Green, A. R., Ellis, I. O., & Rakha, E. A. (2019). Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients. Egyptian Journal of Pathology, 16(1), 115-122. https://doi.org/10.4103/EGJP.EGJP_15_19

• Journal Article Type: Article
• Acceptance Date: Aug 20, 2019
• Online Publication Date: Nov 29, 2019
• Publication Date: Nov 29, 2019
• Deposit Date: Sep 16, 2019
• Publicly Available Date: Nov 30, 2020
• Journal: Egyptian Journal of Pathology
• Electronic ISSN: 2090-5378
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 1
• Pages: 115-122
• DOI: https://doi.org/10.4103/EGJP.EGJP_15_19
• Public URL: https://nottingham-repository.worktribe.com/output/2619643
• Publisher URL: http://www.xep.eg.net/article.asp?issn=1687-4277;year=2019;volume=16;issue=1;spage=115;epage=122;aulast=Mohammed
• Additional Information: Mohammed RA, Mohammed El-Deek HE, Aleskandarany MA, Green AR, Ellis IO, Rakha EA. Clinicopathological characteristics of basal-like breast cancer: a comparative study between Egyptian and British patients. Egypt J Pathol 2019;16:115-22