Continuous-flow crystallisation in 3D-printed compact devices

Okafor, Obinna; Robertson, Karen; Goodridge, Ruth; Sans, Victor

Abstract

© 2019 The Royal Society of Chemistry. A flexible and cost-effective methodology to develop compact flow devices with heat exchange ability is presented here. Additive manufacturing techniques allow the rapid design and manufacture of modular jacketed flow devices, where heat exchange can be modelled and controlled to generate efficient devices for applications in continuous-flow cooling crystallisation. As a proof of concept, the crystallisation of paracetamol has been demonstrated. The manufactured devices are effective in crystallising form II paracetamol employing metacetamol as a co-crystallising agent.

Citation

Okafor, O., Robertson, K., Goodridge, R., & Sans, V. (2019). Continuous-flow crystallisation in 3D-printed compact devices. Reaction Chemistry and Engineering, 4(9), 1682-1688. https://doi.org/10.1039/c9re00188c

• Journal Article Type: Article
• Acceptance Date: Jul 23, 2019
• Online Publication Date: Jul 23, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: Oct 11, 2019
• Publicly Available Date: Jul 24, 2020
• Journal: Reaction Chemistry and Engineering
• Print ISSN: 2058-9883
• Electronic ISSN: 2058-9883
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 9
• Pages: 1682-1688
• DOI: https://doi.org/10.1039/c9re00188c
• Public URL: https://nottingham-repository.worktribe.com/output/2469055
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2019/RE/C9RE00188C#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : Karen Robertson (ORCID); : Victor Sans (ORCID); : Victor Sans (ResearcherID); : Single-blind; : Received 11 May 2019; Accepted 23 July 2019; Accepted Manuscript published 23 July 2019; Advance Article published 6 August 2019; Version of Record published 20 August 2019