Shristi Bhattarai
Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study
Bhattarai, Shristi; Klimov, Sergey; Mittal, Karuna; Krishnamurti, Uma; Li, Bill; Oprea-Ilies, Gabriela; Wetherilt, Ceyda Sonmez; Riaz, Ansa; Aleskandarany, Mohammad A.; Green, Andrew R.; Ellis, Ian O.; Cantuaria, Guilherme; Gupta, Meenakshi; Manne, Upender; Agboola, Johnson; Baskovich, Brett; Janssen, Emiel A.M.; Rakha, Emad; Callagy, Grace; Walsh, Elaine M.; Mehta, Anurag; Shet, Tanuja; Dogra, Atika; Gajaria, Pooja; Nggada, Haruna A.; Omonisi, Abidemi; Traina, Tiffany; Ahmed, Saad A.; Rida, Padmashree; Aneja, Ritu
Authors
Sergey Klimov
Karuna Mittal
Uma Krishnamurti
Bill Li
Gabriela Oprea-Ilies
Ceyda Sonmez Wetherilt
Ansa Riaz
Mohammad A. Aleskandarany
ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology
Guilherme Cantuaria
Meenakshi Gupta
Upender Manne
Johnson Agboola
Brett Baskovich
Emiel A.M. Janssen
EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology
Grace Callagy
Elaine M. Walsh
Anurag Mehta
Tanuja Shet
Atika Dogra
Pooja Gajaria
Haruna A. Nggada
Abidemi Omonisi
Tiffany Traina
Saad A. Ahmed
Padmashree Rida
Ritu Aneja
Abstract
Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients’ prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n=420), UK (n=239), Norway (n=104), Ireland (n=222), Nigeria (n=180), and India (n=242); total n=1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients’ overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted.
Citation
Bhattarai, S., Klimov, S., Mittal, K., Krishnamurti, U., Li, B., Oprea-Ilies, G., …Aneja, R. (2019). Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study. Cancers, 11(7), Article 995. https://doi.org/10.3390/cancers11070995
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 11, 2019 |
Online Publication Date | Jun 17, 2019 |
Publication Date | Jul 17, 2019 |
Deposit Date | Aug 20, 2019 |
Publicly Available Date | Jun 19, 2020 |
Journal | Cancers |
Electronic ISSN | 2072-6694 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 7 |
Article Number | 995 |
DOI | https://doi.org/10.3390/cancers11070995 |
Public URL | https://nottingham-repository.worktribe.com/output/2450035 |
Publisher URL | https://www.mdpi.com/2072-6694/11/7/995 |
Files
AR CANCERS
(1.4 Mb)
PDF
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search