The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis

El Shamy, Tarek; Amer, Saad A.K.; Mohamed, Ahmed; James, Cathryn; Jayaprakasan, Kannamannadiar

Abstract

Introduction: Uterine artery embolization (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been growing concern over the risk of unintended embolization of the utero-ovarian circulation, leading to reduction of ovarian blood supply with subsequent impairment of ovarian reserve. The purpose of this study was to investigate the impact of UAE on circulating anti-Müllerian hormone (AMH) and other markers of ovarian reserve. Material and methods: This meta-analysis included all published cohort, cross-sectional and case-control studies, as well as randomized trials that investigated the impact of UAE on circulating AMH. Data sources included MEDLINE, EMBASE, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and the Cochrane Library from January 2000 to June 2019. All identified articles were screened, and articles were selected based on the inclusion and exclusion criteria. AMH and other data were extracted from the eligible articles and entered into RevMan software to calculate the weighted mean difference between pre- and post-embolization values. PROSPERO registration number: CRD42017082615. Results: This review included 3 cohort and 3 case-control studies (n=353). The duration of follow up after UAE ranged between 3 and 12months. Overall pooled analysis of all studies showed no significant effect of UAE on serum AMH levels (weighted mean difference –0.58ng/mL; 95% CI –1.5 to 0.36, I2=95%). Subgroup analysis according to age of participants (under and over 40years) and according to follow-up duration (3, 6 and 12months) showed no significant change in post-embolization circulating AMH. Pooled analysis of serum follicle-stimulating hormone (FSH) concentrations (4 studies, n=248) revealed no statistically significant change after UAE (weighted mean difference 4.32; 95% CI –0.53 to 9.17; I2=95%). Analysis of 2 studies (n=62) measuring antral follicle count showed a significant decline at 3-month follow up (weighted mean difference –3.28; 95% CI –5.62 to –0.93; I2=94%). Conclusions: Uterine artery embolization for uterine fibroids does not seem to affect ovarian reserve as measured by serum concentrations of AMH and FSH.

Citation

El Shamy, T., Amer, S. A., Mohamed, A., James, C., & Jayaprakasan, K. (2020). The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 99(1), 16-23. https://doi.org/10.1111/aogs.13698

• Journal Article Type: Review
• Acceptance Date: Aug 1, 2019
• Online Publication Date: Aug 1, 2019
• Publication Date: Jan 1, 2020
• Deposit Date: Aug 4, 2019
• Publicly Available Date: Aug 2, 2020
• Journal: Acta Obstetricia et Gynecologica Scandinavica
• Print ISSN: 0001-6349
• Electronic ISSN: 1600-0412
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 99
• Issue: 1
• Pages: 16-23
• DOI: https://doi.org/10.1111/aogs.13698
• Keywords: Uterine artery embolization; Ovarian reserve; Anti-Müllerian hormone; Antral Follicle
• Public URL: https://nottingham-repository.worktribe.com/output/2386238
• Publisher URL: https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13698
• Additional Information: This is the peer reviewed version of the following article: Shamy, T. E., Amer, S. , Mohamed, A. , James, C. and Jayaprakasan, K. (2019), The impact of uterine artery embolization on ovarian reserve: a systematic review and meta‐analysis. Acta Obstet Gynecol Scand. , which has been published in final form at https://doi.org/10.1111/aogs.13698
• Contract Date: Aug 4, 2019