Salih Atalah Alenezi
The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis
Alenezi, Salih Atalah; Elkmeshi, Nusaiba; Alanazi, Abdullah; Alanazi, Sulaiman T.; Khan, Raheela; Amer, Saad
Authors
Nusaiba Elkmeshi
Abdullah Alanazi
Sulaiman T. Alanazi
RAHEELA KHAN RAHEELA.KHAN@NOTTINGHAM.AC.UK
Professor of Cellular Physiology
SAAD AMER saad.amer@nottingham.ac.uk
Professor of Gynaecology and Reproductive Medicine
Abstract
Background: Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary interventions on inflammatory status and hyperandrogenism in PCOS women. Methods: A comprehensive search was conducted to identify randomised controlled trials (RCTs) and cohort studies assessing the impact of diet-induced weight loss on circulating inflammatory markers (CRP, IL-6, IL-1β, TNF-α), androgens (testosterone, androstenedione), SHBG, and luteinising hormone (LH) in PCOS women. The quality and risk of bias of the included studies were assessed using the Cochrane Collaboration’s tool for RCTs and the Newcastle–Ottawa Scale for cohort studies. Data were entered into RevMan software v5.9 for the calculation of standard mean difference (SMD) and the 95% confidence interval (95%CI) of circulating inflammatory markers, androgens, and LH between baseline and post-weight loss values. Results: Eleven studies (n = 323) were eligible for the systematic review, of which nine (n = 286) were included in the meta-analysis. Pooled analysis of data revealed a statistically significant decrease in circulating CRP (SMD 0.39, 95%CI 0.22, 0.56; 9 studies, n = 286), IL-6 (SMD 0.37, 95%Cl, 0.12, 0.61; 3 Studies, n = 140), TNF-α (SMD 0.30, 95%Cl, 0.07, 0.53; 4 Studies, n = 162), androstenedione (SMD 0.36, 95%Cl, 0.13, 0.60; 4 studies, n = 147) and LH (SMD 0.30, 95% Cl, 0.09, 0.51; 5 studies, n = 197) after weight loss compared to baseline levels among PCOS women. A meta-analysis of five studies (n = 173) showed a statistically significant increase in circulating SHBG after weight loss compared to baseline levels (SMD −0.43, 95%Cl, −0.65, −0.21). Conclusions: These findings suggest that weight loss induced by dietary interventions seems to improve PCOS-related chronic inflammation and hyperandrogenism. The possible causative relationship between the improvement in inflammation and hyperandrogenism remains to be determined.
Citation
Alenezi, S. A., Elkmeshi, N., Alanazi, A., Alanazi, S. T., Khan, R., & Amer, S. (2024). The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(16), Article 4934. https://doi.org/10.3390/jcm13164934
Journal Article Type | Review |
---|---|
Acceptance Date | Aug 16, 2024 |
Online Publication Date | Aug 21, 2024 |
Publication Date | 2024-08 |
Deposit Date | Aug 24, 2024 |
Publicly Available Date | Aug 27, 2024 |
Journal | Journal of Clinical Medicine |
Electronic ISSN | 2077-0383 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 16 |
Article Number | 4934 |
DOI | https://doi.org/10.3390/jcm13164934 |
Public URL | https://nottingham-repository.worktribe.com/output/38650003 |
Publisher URL | https://www.mdpi.com/2077-0383/13/16 |
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The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)—A Systematic Review and Meta-Analysis
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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