Sarah J Bailey
Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP)
Bailey, Sarah J; Bast, Tobias; Chaby, Lauren; Kinon, Bruce J; Harte, Michael K; Mead, Sally; Moloney, Rachel D; Ragan, Ian; Stanford, S Clare; Tricklebank, Mark D; Zervas, Mark; Ajram, Laura A
Authors
TOBIAS BAST tobias.bast@nottingham.ac.uk
Associate Professor
Lauren Chaby
Bruce J Kinon
Michael K Harte
Sally Mead
Rachel D Moloney
Ian Ragan
S Clare Stanford
Mark D Tricklebank
Mark Zervas
Laura A Ajram
Abstract
Animal models are important in preclinical psychopharmacology to study mechanisms and potential treatments for psychiatric disorders. A working group of 14 volunteers, comprising an international team of researchers from academia and industry, convened in 2021 to discuss how to improve the translational relevance and interpretation of findings from animal models that are used in preclinical psychopharmacology. The following paper distils the outcomes of the working group’s discussions into 10 key considerations for the planning and reporting of behavioural studies in animal models relevant to psychiatric disorders. These form the iTRIPP guidelines (Improving Translational Relevance In Preclinical Psychopharmacology). These guidelines reflect the key considerations that the group thinks will likely have substantial impact in terms of improving the translational relevance of behavioural studies in animal models that are used to study psychiatric disorders and their treatment. They are relevant to the research community when drafting and reviewing manuscripts, presentations and grant applications. The iTRIPP guidelines are intended to complement general recommendations for planning and reporting animal studies that have been published elsewhere, by enabling researchers to fully consider the most appropriate animal model for the research purpose and to interpret their findings appropriately. This in turn will increase the clinical benefit of such research and is therefore important not only for the scientific community but also for patients and the lay public.
Citation
Bailey, S. J., Bast, T., Chaby, L., Kinon, B. J., Harte, M. K., Mead, S., …Ajram, L. A. (2023). Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP). Journal of Psychopharmacology, 37(11), 1051-1057. https://doi.org/10.1177/02698811231182607
Journal Article Type | Article |
---|---|
Acceptance Date | May 30, 2023 |
Online Publication Date | Jul 31, 2023 |
Publication Date | 2023-11 |
Deposit Date | Aug 1, 2023 |
Publicly Available Date | Aug 2, 2023 |
Journal | Journal of Psychopharmacology |
Print ISSN | 0269-8811 |
Electronic ISSN | 1461-7285 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 37 |
Issue | 11 |
Pages | 1051-1057 |
DOI | https://doi.org/10.1177/02698811231182607 |
Keywords | Psychopharmacology, animal models, psychiatric disorders, preclinical research, translation |
Public URL | https://nottingham-repository.worktribe.com/output/23663171 |
Publisher URL | https://journals.sagepub.com/doi/10.1177/02698811231182607 |
Files
bailey-et-al-2023-improving-translational-relevance-in-preclinical-psychopharmacology-itripp
(234 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
You might also like
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search