A single-arm, phase II study of the anti-BLYS monoclonal antibody belimumab in symptomatic waldenstrom macroglobulinemia

Bishton, Mark; Spencer, Andrew; Dickinson, Michael; Ritchie, David

Abstract

Background: The B-lymphocyte stimulator (BLYS) protein is known to regulate immunoglobulin in normal B cells, and be overexpressed in B-cell malignancies, including Waldenstrom macroglobulinemia (WM). Patients and Methods: This trial evaluated the safety and activity of belimumab, a monoclonal antibody targeting BLYS, in 12 patients with WM in a single-arm phase II study. Results: Ten patients had stable disease with therapy, although no objective responses were seen. Correlative studies showed patients to have low or undetectable baseline serum levels of BLYS, with the administration of belimumab having no effect on B-cell numbers. Conclusion: Belimumab cannot be recommended as a single-agent therapy for the treatment of symptomatic WM, although further evaluation in combination with other agents would be justified. © 2013 Elsevier Inc. All rights reserved.

Citation

Bishton, M., Spencer, A., Dickinson, M., & Ritchie, D. (2013). A single-arm, phase II study of the anti-BLYS monoclonal antibody belimumab in symptomatic waldenstrom macroglobulinemia. Clinical Lymphoma, Myeloma and Leukemia, 13(5), 575-578. https://doi.org/10.1016/j.clml.2013.04.006

• Journal Article Type: Article
• Online Publication Date: Jun 17, 2013
• Publication Date: Oct 1, 2013
• Deposit Date: Nov 10, 2023
• Journal: Clinical Lymphoma, Myeloma and Leukemia
• Print ISSN: 2152-2650
• Electronic ISSN: 2152-2669
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 5
• Pages: 575-578
• DOI: https://doi.org/10.1016/j.clml.2013.04.006
• Keywords: Cancer Research; Oncology; Hematology
• Public URL: https://nottingham-repository.worktribe.com/output/23550708
• Publisher URL: https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(13)00124-9/fulltext